Increasing body of evidence suggests that there exists a connection between diabetes and
cancer. Nevertheless, to date, the potential reasons for this association are still poorly …

Diabetes and cancer are worldwide chronic diseases with a major impact on the quality and
expectancy of life. Metabolic abnormalities observed during the onset and progression of …

Diabetes is a disease involving metabolic derangements in multiple organs. While the
spectrum of diabetic complications has been known for years, recent evidence suggests that …

Diabetes mellitus is a serious and growing health problem worldwide and is associated with
severe acute and chronic complications. Accruing epidemiological and clinical evidence …

Cancer incidence and mortality are higher among diabetic patients. This review examines
the mechanisms, both general and site-specific, for this increase. Hyperglycemia and …

The association of cancer and diabetes mellitus (DM) has been studied for decades.
Hyperglycemia and the imbalance of hormones are factors that contribute to the molecular …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

In recent years, the significant impact of lactate in the tumor microenvironment has been
greatly documented. Acting not only as an energy substance in tumor metabolism, lactate is …

Recent evidence from large cohort studies suggests that there exists a higher cancer
incidence in people with type 2 diabetes (DM2). However, to date, the potential reasons for …

Cancer is considered the second leading cause of death worldwide and in 2018 it was
responsible for approximately 9.6 million deaths. Globally, about one in six deaths are …