Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …

Abstract Ataxia‐telangiectasia (A‐T) is a genetic disorder caused by the lack of functional
ATM kinase. A‐T is characterized by chronic inflammation, neurodegeneration and …

Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated
impairment and disease. Multiple factors can contribute to ageing-associated inflammation; …

Recognition of foreign or misplaced nucleic acids is one of the principal modes by which the
immune system detects pathogenic entities. When cytosolic DNA is sensed, a signal is …

The innate immune system is strongly implicated in the pathogenesis of Alzheimer's disease
(AD). In contrast, the role of adaptive immunity in AD remains largely unknown. However …

Alzheimer's disease (AD) is known as the most predominant cause of dementia among the
aged people. Previously, two hallmarks of AD pathology including extracellular amyloid-β …

Aging adversely affects inflammatory processes in the brain, which has important
implications in the progression of neurodegenerative disease. Following traumatic brain …

Innate immune responses are considered to play crucial roles in the progression of
Alzheimer's disease (AD). Recently, immunotherapy is emerging as an innovative and …

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and
sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory …

Cellular senescence is a plausible mediator of inflammation-related tissue dysfunction. In
the aged brain, senescent cell identities and the mechanisms by which they exert adverse …