K-nearest-neighbors induced topological PCA for single cell RNA-sequence data analysis

S Cottrell, Y Hozumi, GW Wei - Computers in biology and medicine, 2024 - Elsevier
Single-cell RNA sequencing (scRNA-seq) is widely used to reveal heterogeneity in cells,
which has given us insights into cell–cell communication, cell differentiation, and differential …

PLPCA: persistent laplacian-enhanced PCA for microarray data analysis

S Cottrell, R Wang, GW Wei - Journal of chemical information and …, 2023 - ACS Publications
Over the years, Principal Component Analysis (PCA) has served as the baseline approach
for dimensionality reduction in gene expression data analysis. Its primary objective is to …

Correspondence analysis for dimension reduction, batch integration, and visualization of single-cell RNA-seq data

LL Hsu, AC Culhane - Scientific Reports, 2023 - nature.com
Effective dimension reduction is essential for single cell RNA-seq (scRNAseq) analysis.
Principal component analysis (PCA) is widely used, but requires continuous, normally …

Preprocessing of single cell RNA sequencing data using correlated clustering and projection

Y Hozumi, KA Tanemura, GW Wei - Journal of chemical …, 2023 - ACS Publications
Single-cell RNA sequencing (scRNA-seq) is widely used to reveal heterogeneity in cells,
which has given us insights into cell–cell communication, cell differentiation, and differential …

Edge-group sparse PCA for network-guided high dimensional data analysis

W Min, J Liu, S Zhang - Bioinformatics, 2018 - academic.oup.com
Motivation Principal component analysis (PCA) has been widely used to deal with high-
dimensional gene expression data. In this study, we proposed an Edge-group Sparse PCA …

Visualizing single-cell RNA-seq data with semisupervised principal component analysis

Z Liu - International journal of molecular sciences, 2020 - mdpi.com
Single-cell RNA-seq (scRNA-seq) is a powerful tool for analyzing heterogeneous and
functionally diverse cell population. Visualizing scRNA-seq data can help us effectively …

A topology-preserving dimensionality reduction method for single-cell RNA-seq data using graph autoencoder

Z Luo, C Xu, Z Zhang, W Jin - Scientific reports, 2021 - nature.com
Dimensionality reduction is crucial for the visualization and interpretation of the high-
dimensional single-cell RNA sequencing (scRNA-seq) data. However, preserving …

Analyzing Single Cell RNA Sequencing with Topological Nonnegative Matrix Factorization

Y Hozumi, GW Wei - arXiv preprint arXiv:2310.15744, 2023 - arxiv.org
Single-cell RNA sequencing (scRNA-seq) is a relatively new technology that has stimulated
enormous interest in statistics, data science, and computational biology due to the high …

Accelerated dimensionality reduction of single-cell RNA sequencing data with fastglmpca

E Weine, P Carbonetto, M Stephens - Bioinformatics, 2024 - academic.oup.com
Motivated by theoretical and practical issues that arise when applying Principal component
analysis (PCA) to count data, Townes et al. introduced “Poisson GLM-PCA”, a variation of …

Dimensionality reduction of single-cell RNA-seq data

GC Linderman - RNA Bioinformatics, 2021 - Springer
Dimensionality reduction is a crucial step in essentially every single-cell RNA-sequencing
(scRNA-seq) analysis. In this chapter, we describe the typical dimensionality reduction …