Rapid, saturable, specific and stereoselective binding of L-dopa to crude membranes and
membranes and purified nuclei from rodent amelanotic melanoma cells is reported. Cross …

A new class of compounds, termed “dopa phosphates,” is described. The compounds
contain phosphate ester linkages at positions 3 and/or 4 of the phenylalanine ring. Dopa …

L‐DOPA had no effect on the endogenous phosphorylation of proteins after extraction with
1% Triton X‐100 from hamster melanoma. When proteins were purified further by wheat …

Melanoma cells possess a special biochemical pathway for the conversion of L-dopa to
melanin. Selective incorporation of exogenous L-dopa into melanoma cells in vivo has been …

A variety of factors were found to modify the toxicity of l-dopa in HeLa cells (D 37 16 μM) and
in dopa-sensitive, nonpigmented human melanoma cells (MM96)(D 37 5 μM) having a …

Free dopa and 5-S-cysteinyldopa were extracted from two human melanomas. Subsequent
hydrolysis of carefully washed melanoma tissue released dopa and 5-S-cysteinyldopa …

Dopamine interaction with target cells undoubtably involves binding to plasma membrane
receptors. However, the well documented cell growth inhibitory activity of this catecholamine …

The biosynthetic pathway producing melanin is present in many melanomas. Previous
investigations have suggested that pharmacologic levels of intermediates in this pathway (L …

L-DOPA, the product of enzymatic hydroxylation of L-tyrosine, is released by melanotic
melanoma cells in vivo and in vitro. Here we report that DOPA at pharmacologically relevant …

Summary Crosslinking of [14 C] l-tyrosine to at least five hamster melanoma cell surface
proteins is reported. This effect was abolished by addition of nonradioactive l-tyrosine, l …