Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease

B Wolozin, SW Wang, NC Li, A Lee, TA Lee, LE Kazis - BMC medicine, 2007 - Springer
Background Statins are a class of medications that reduce cholesterol by inhibiting 3-
hydroxy-3-methylglutaryl-coenzyme A reductase. Whether statins can benefit patients with …

Statin use and the risk of incident dementia: the Cardiovascular Health Study

TD Rea, JC Breitner, BM Psaty, AL Fitzpatrick… - Archives of …, 2005 - jamanetwork.com
Background Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduce
cardiovascular risk through mechanisms that might affect the development of dementia …

Statins in the prevention of dementia and Alzheimer's disease: a meta‐analysis of observational studies and an assessment of confounding

WB Wong, VW Lin, D Boudreau… - … and drug safety, 2013 - Wiley Online Library
Background Studies demonstrate the potential for statins to prevent dementia and
Alzheimer's disease (AD), but the evidence is inconclusive. Objective Conduct a meta …

Association between use of statin and risk of dementia: a meta-analysis of observational studies

TN Poly, MM Islam, BA Walther, HC Yang, CC Wu… - …, 2020 - karger.com
Abstract Background and Aims: The impact of statin on dementia risk reduction has been a
subject of debate over the last decade, but the evidence remains inconclusive. Therefore …

Statins use and risk of dementia: A dose–response meta analysis

X Zhang, J Wen, Z Zhang - Medicine, 2018 - journals.lww.com
Previous studies have indicated that statins use is associated with risk of dementia, but
presented controversial results. Medline, Embase, Web of Science, and the Cochrane …

Prevention and treatment of dementia or Alzheimer's disease by statins: a meta-analysis

B Zhou, S Teramukai, M Fukushima - Dementia and geriatric cognitive …, 2007 - karger.com
Abstract Background/Aim: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
(statins) are thought to reduce the amount of Abeta peptides by reducing cholesterol from …

The impact of the use of statins on the prevalence of dementia and the progression of cognitive impairment

I Hajjar, J Schumpert, V Hirth, D Wieland… - The Journals of …, 2002 - academic.oup.com
Background. Previous evidence suggests that treatment with 3-hydroxy-3-methylglutaryl-
coenzyme-A reductase inhibitors (statins) has a positive impact on dementia. We decided to …

Statin therapy and risk of Alzheimer's and age‐related neurodegenerative diseases

G Torrandell‐Haro, GL Branigan, F Vitali… - … Research & Clinical …, 2020 - Wiley Online Library
Introduction Establishing efficacy of and molecular pathways for statins has the potential to
impact incidence of Alzheimer's and age‐related neurodegenerative diseases (NDD) …

Use of statins and the risk of dementia and mild cognitive impairment: A systematic review and meta-analysis

CS Chu, PT Tseng, B Stubbs, TY Chen, CH Tang… - Scientific reports, 2018 - nature.com
We conducted a systematic review and meta-analysis to investigate whether the use of
statins could be associated with the risk of all-caused dementia, Alzheimer's disease (AD) …

Sex and race differences in the association between statin use and the incidence of Alzheimer disease

JM Zissimopoulos, D Barthold, RD Brinton… - JAMA …, 2017 - jamanetwork.com
Importance To our knowledge, no effective treatments exist for Alzheimer disease, and new
molecules are years away. However, several drugs prescribed for other conditions have …