Therapeutic effect of finasteride through its antiandrogenic and antioxidant role in a propionic acid-induced autism model: Demonstrated by behavioral tests …

IH Sever, B Ozkul, MF Bozkurt, O Erbas - Neuroscience letters, 2022 - Elsevier
Background Autism is a clinically defined neurodevelopmental disorder with unknown origin
characterized by significant social, communication and behavioral challenges. Although it …

Demonstration of ameliorating effect of vardenafil through its anti-inflammatory and neuroprotective properties in autism spectrum disorder induced by propionic acid …

B Özkul, FE Urfalı, IH Sever, MF Bozkurt… - International Journal …, 2022 - Taylor & Francis
Introduction Autism spectrum disorder (ASD) is a neurodevelopmental disorder with
complex etiology. In this study, we aimed to determine the ameliorating effects of vardenafil …

[HTML][HTML] Torasemide improves the propionic acid-induced autism in rats: A histopathological and imaging study

M Doğan, Y Albayrak, O Erbaş - Alpha Psychiatry, 2023 - ncbi.nlm.nih.gov
Objective: Autism spectrum disorder is a neurodevelopmental disease in which impaired
social behaviors, impaired sociality, and restricted and repetitive behaviors are seen …

Novel role of peroxisome proliferator activated receptor-α in valproic acid rat model of autism: Mechanistic study of risperidone and metformin monotherapy versus …

EM Elnahas, SA Abuelezz, MI Mohamad… - Progress in Neuro …, 2022 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder of heterogenous etiology
exhibiting a challenge in understanding its exact neuro-pathophysiology. Recently …

Finasteride inhibited brain dopaminergic system and open‐field behaviors in adolescent male rats

L Li, YX Kang, XM Ji, YK Li, SC Li… - CNS neuroscience & …, 2018 - Wiley Online Library
Aims Finasteride inhibits the conversion of testosterone to dihydrotestosterone. Because
androgen regulates dopaminergic system in the brain, it could be hypothesized that …

Selective modulator of peroxisome proliferator-activated receptor-α protects propionic acid induced autism-like phenotypes in rats

R Mirza, B Sharma - Life sciences, 2018 - Elsevier
Aims The present study investigated the neuropharmacological role of PPAR-α modulator,
fenofibrate in postnatal-propionic acid induced symptomatology related with autism …

Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in …

A Nadeem, SF Ahmad, NO Al-Harbi, SM Attia… - Behavioural brain …, 2019 - Elsevier
Autism is a neurodevelopmental disease which is characterized by its core behavioral
symptoms such as impairment in social interaction and stereotyped repetitive behavior …

Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐and anxiolytic‐like effects in female rats

J Nayana, BS Shankaranarayana Rao… - Journal of …, 2024 - Wiley Online Library
Finasteride is used in female‐pattern hair loss, hirsutism, and polycystic ovarian syndrome. It
inhibits 5α‐reductase, which is an important enzyme in the biosynthesis of neurosteroids …

[PDF][PDF] Atorvastatin improves the propionic acid-induced autism in rats: The roles of sphingosine-1-phosphate and anti-inflammatory action

F Durankuş, K Budak, Y Albayrak, İH Sever, B Özkul… - Cureus, 2023 - cureus.com
Atorvastatin Improves the Propionic Acid- Induced Autism in Rats: The Roles of Sphingosine-1-Phosphate
and Anti-inflammatory Act Page 1 Review began 02/10/2023 Review ended 03/18/2023 …

[PDF][PDF] Cognitive dysfunction and bumetanide treatment in a valproate-induced rat model of autism

S Liu, F Jia, T Xia, N Xu, Y Zhang, H Jiang - Int J Clin Exp Med, 2016 - e-century.us
Cognitive dysfunction is an important aspect of the clinical characteristics of autism;
however, research has often focused on social cognition. Learning and memory disorders …