Background The neocortex, including the medial prefrontal cortex (mPFC), contains many
neurons expressing nitric oxide synthase (NOS). In addition, increasing evidence shows that …

BACKGROUND: Partial nerve injury to a peripheral nerve may induce the development of
neuropathic pain which is characterized by symptams such as spontaneous burning pain …

Background: The local administration of μ-opioid receptor (MOR) agonists attenuates
neuropathic pain but the precise mechanism implicated in this effect is not completely …

Background: Nitric oxide (NO) is involved in the transmission and modulation of nociceptive
information at the peripheral, spinal cord and supraspinal levels. We conducted this …

Lots of studies have demonstrated that anterior cingulate cortex plays important roles in the
pain perception and pain modulation. The present study explored the role of mu-opioid …

The controversy over using opiods for managing chronic neuropathic pain is widely
acknowledged, and nitric oxide (NO) is suggested to play an important role in the …

Background Recent studies indicate that reactive oxygen species (ROS) are involved in
persistent pain, including neuropathic and inflammatory pain. Since the data suggest that …

THIS study was conducted to determine whether nitric oxide (NO) is involved in the
maintenance of behavioral signs of neuropathic pain induced by tightly ligating the left L5 …

Background Nitric oxide (NO) levels in brain nuclei, such as the hippocampus and
brainstem, are involved in morphine analgesia, but the relationship between the dorsal …

Our study was designed to determine involvement of nitric oxide (NO) in the antinociception
mediated by mu, delta andkappa opioid receptors in acute and prolonged pain in the rat …