Abstract Background The Blood Brain Barrier (BBB) maintains the homeostasis of central
nervous system by preventing the free passage of macromolecules from the systemic …

Ultrasound-induced opening of the blood–brain barrier (BBB) is an emerging technique for
targeted drug delivery to the central nervous system. Gap junctions allow transfer of …

Focused ultrasound (FUS) in the presence of microbubbles transiently and reversibly opens
the blood-brain barrier (BBB) in rodents and humans, thereby providing a time window for …

The blood–brain barrier (BBB) is a specialized system of capillary endothelial cells that
protects the brain from harmful substances in the blood stream, while supplying the brain …

Delivery of therapeutic or diagnostic agents to the brain is majorly hindered by the blood–
brain barrier (BBB). Recently, many studies have demonstrated local and transient …

With focused ultrasound (FUS) and microbubbles, BBB can be transiently disrupted with a
localized and non-invasive approach. BBB disruption induced by FUS has made …

The blood–brain barrier (BBB) continues to represent one of the most significant challenges
for successful drug-based treatments of neurological disease. Mechanical modulation of the …

Local blood-brain barrier (BBB) opening is an advantageous approach for targeted drug
delivery to the brain. Recently, it has been shown that focused ultrasound (US) exposures …

Previous studies have investigated a potential method for targeted drug delivery in the
central nervous system that uses focused ultrasound bursts combined with an ultrasound …

Rationale: Localized blood-brain barrier (BBB) opening can be achieved with minimal to no
tissue damage by applying pulsed focused ultrasound alongside a low microbubble (MB) …