Orientia tsutsugamushi Stimulates an Original Gene Expression Program in Monocytes: Relationship with Gene Expression in Patients with Scrub Typhus

W Tantibhedhyangkul, T Prachason… - PLoS neglected …, 2011 - journals.plos.org
Orientia tsutsugamushi is the causal agent of scrub typhus, a public health problem in the
Asia-Pacific region and a life-threatening disease. O. tsutsugamushi is an obligate …

Orientia tsutsugamushi, the causative agent of scrub typhus, induces an inflammatory program in human macrophages

W Tantibhedhyangkul, AB Amara, J Textoris… - Microbial …, 2013 - Elsevier
Scrub typhus is a life-threatening disease caused by Orientia tsutsugamushi, a bacterium
that primarily infects endothelial cells both in vitro and in vivo. Evidence suggests that the …

Strong Type 1, but Impaired Type 2, Immune Responses Contribute to Orientia tsutsugamushi-Induced Pathology in Mice

L Soong, H Wang, TR Shelite, Y Liang… - PLoS neglected …, 2014 - journals.plos.org
Scrub typhus is a neglected, but important, tropical disease, which puts one-third of the
world's population at risk. The disease is caused by Orientia tsutsugamushi, an obligately …

Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium

DH Paris, R Phetsouvanh… - PLoS neglected …, 2012 - journals.plos.org
Scrub typhus is a common and underdiagnosed cause of febrile illness in Southeast Asia,
caused by infection with Orientia tsutsugamushi. Inoculation of the organism at a cutaneous …

Expression of Chemokine Genes in Murine Macrophages Infected with Orientia tsutsugamushi

NH Cho, SY Seong, MS Huh, TH Han… - Infection and …, 2000 - Am Soc Microbiol
Scrub typhus, caused by Orientia tsutsugamushi infection, is characterized by local as well
as systemic inflammatory manifestations. Inflammation is initiated by O. tsutsugamushi …

Chemokine and cytokine production during Orientia tsutsugamushi infection in mice

YS Koh, JH Yun, SY Seong, MS Choi, IS Kim - Microbial pathogenesis, 2004 - Elsevier
Orientia tsutsugamushi, an obligate intracellular bacterium, is the causative agent of scrub
typhus which is histopathologically characterized by inflammatory manifestations, indicating …

Dissemination of Orientia tsutsugamushi and Inflammatory Responses in a Murine Model of Scrub Typhus

CA Keller, M Hauptmann, J Kolbaum… - PLoS neglected …, 2014 - journals.plos.org
Central aspects in the pathogenesis of scrub typhus, an infection caused by Orientia (O.)
tsutsugamushi, have remained obscure. Its organ and cellular tropism are poorly …

Orientia tsutsugamushi inhibits tumor necrosis factor α production by inducing interleukin 10 secretion in murine macrophages

MJ Kim, MK Kim, JS Kang - Microbial pathogenesis, 2006 - Elsevier
Orientia tsutsugamushi (OT) is the causative agent of scrub typhus or Tsutsugamushi
disease. We have previously reported that OT suppresses the production of inflammatory …

A Hematogenously Disseminated Orientia tsutsugamsushi-Infected Murine Model of Scrub Typhus

TR Shelite, TB Saito, NL Mendell, B Gong… - PLoS neglected …, 2014 - journals.plos.org
Orientia tsutsugamushi, the etiologic agent of scrub typhus, is a mite-borne rickettsia
transmitted by the parasitic larval stage of trombiculid mites. Approximately one-third of the …

Orientia tsutsugamushi Bacteremia and Cytokine Levels in Vietnamese Scrub Typhus Patients

S Kramme, L Van An, ND Khoa, L Van Trin… - Journal of clinical …, 2009 - Am Soc Microbiol
Scrub typhus, caused by the intracellular bacterium Orientia tsutsugamushi, is a major cause
of febrile illness in the Asia/Pacific region. Here, we implemented a novel real-time PCR and …