Bond-selective intensity diffraction tomography

J Zhao, A Matlock, H Zhu, Z Song, J Zhu… - Nature …, 2022 - nature.com
Recovering molecular information remains a grand challenge in the widely used
holographic and computational imaging technologies. To address this challenge, we …

Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy

J Zhao, L Jiang, A Matlock, Y Xu, J Zhu, H Zhu… - Light: Science & …, 2023 - nature.com
Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases.
However, it remains a grand challenge to extract molecular structure information from …

[HTML][HTML] Deep image restoration for infrared photothermal heterodyne imaging

S Zhang, K Kniazev, IM Pavlovetc, S Zhang… - The Journal of …, 2021 - pubs.aip.org
Infrared photothermal heterodyne imaging (IR-PHI) is an all-optical table top approach that
enables super-resolution mid-infrared microscopy and spectroscopy. The underlying …

Depth-resolved mid-infrared photothermal imaging of living cells and organisms with submicrometer spatial resolution

D Zhang, C Li, C Zhang, MN Slipchenko, G Eakins… - Science …, 2016 - science.org
Chemical contrast has long been sought for label-free visualization of biomolecules and
materials in complex living systems. Although infrared spectroscopic imaging has come a …

Infrared spectroscopic laser scanning confocal microscopy for whole-slide chemical imaging

K Yeh, I Sharma, K Falahkheirkhah, MP Confer… - Nature …, 2023 - nature.com
Chemical imaging, especially mid-infrared spectroscopic microscopy, enables label-free
biomedical analyses while achieving expansive molecular sensitivity. However, its slow …

High-speed in vitro intensity diffraction tomography

J Li, A Matlock, Y Li, Q Chen, C Zuo… - Advanced …, 2019 - spiedigitallibrary.org
We demonstrate a label-free, scan-free intensity diffraction tomography technique utilizing
annular illumination (aIDT) to rapidly characterize large-volume three-dimensional (3-D) …

High-throughput intensity diffraction tomography with a computational microscope

R Ling, W Tahir, HY Lin, H Lee, L Tian - Biomedical optics express, 2018 - opg.optica.org
We demonstrate a motion-free intensity diffraction tomography technique that enables the
direct inversion of 3D phase and absorption from intensity-only measurements for weakly …

Ultrafast chemical imaging by widefield photothermal sensing of infrared absorption

Y Bai, D Zhang, L Lan, Y Huang, K Maize… - Science …, 2019 - science.org
Infrared (IR) imaging has become a viable tool for visualizing various chemical bonds in a
specimen. The performance, however, is limited in terms of spatial resolution and imaging …

Resolution-enhanced intensity diffraction tomography in high numerical aperture label-free microscopy

J Li, A Matlock, Y Li, Q Chen, L Tian, C Zuo - Photonics Research, 2020 - opg.optica.org
We propose label-free and motion-free resolution-enhanced intensity diffraction tomography
(reIDT) recovering the 3D complex refractive index distribution of an object. By combining an …

Nanosecond-resolution photothermal dynamic imaging via MHZ digitization and match filtering

J Yin, L Lan, Y Zhang, H Ni, Y Tan, M Zhang… - Nature …, 2021 - nature.com
Photothermal microscopy has enabled highly sensitive label-free imaging of absorbers, from
metallic nanoparticles to chemical bonds. Photothermal signals are conventionally detected …