Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways

KA Page, O Chan, J Arora, R Belfort-DeAguiar… - Jama, 2013 - jamanetwork.com
Importance Increases in fructose consumption have paralleled the increasing prevalence of
obesity, and high-fructose diets are thought to promote weight gain and insulin resistance …

Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans

JQ Purnell, BA Klopfenstein, AA Stevens… - Diabetes, Obesity …, 2011 - Wiley Online Library
Aims: In animals, intracerebroventricular glucose and fructose have opposing effects on
appetite and weight regulation. In humans, functional brain magnetic resonance imaging …

Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards

S Luo, JR Monterosso, K Sarpelleh… - Proceedings of the …, 2015 - National Acad Sciences
Prior studies suggest that fructose compared with glucose may be a weaker suppressor of
appetite, and neuroimaging research shows that food cues trigger greater brain reward …

Altered brain response to drinking glucose and fructose in obese adolescents

AM Jastreboff, R Sinha, J Arora, C Giannini, J Kubat… - Diabetes, 2016 - Am Diabetes Assoc
Increased sugar-sweetened beverage consumption has been linked to higher rates of
obesity. Using functional MRI, we assessed brain perfusion responses to drinking two …

[HTML][HTML] The human brain produces fructose from glucose

JJ Hwang, L Jiang, M Hamza, F Dai… - JCI insight, 2017 - ncbi.nlm.nih.gov
Fructose has been implicated in the pathogenesis of obesity and type 2 diabetes. In contrast
to glucose, CNS delivery of fructose in rodents promotes feeding behavior. However …

[HTML][HTML] Effects of dietary glycemic index on brain regions related to reward and craving in men

BS Lennerz, DC Alsop, LM Holsen, E Stern… - The American journal of …, 2013 - Elsevier
Background: Qualitative aspects of diet influence eating behavior, but the physiologic
mechanisms for these calorie-independent effects remain speculative. Objective: We …

Sugar consumption, metabolic disease and obesity: The state of the controversy

KL Stanhope - Critical reviews in clinical laboratory sciences, 2016 - Taylor & Francis
The impact of sugar consumption on health continues to be a controversial topic. The
objective of this review is to discuss the evidence and lack of evidence that allows the …

[HTML][HTML] Effects of high-fructose diets on central appetite signaling and cognitive function

K Lowette, L Roosen, J Tack, P Vanden Berghe - Frontiers in nutrition, 2015 - frontiersin.org
The consumption of fructose has increased tremendously over the last five decades, which
is to a large extent due to the development of high-fructose corn syrup (HFCS), a commercial …

[HTML][HTML] Resting-state functional connectivity of brain regions involved in cognitive control, motivation, and reward is enhanced in obese females

MA Lips, MA Wijngaarden, J van der Grond… - The American journal of …, 2014 - Elsevier
Background: The brain is crucial for the control of food intake, reward, and energy
homeostasis. Objective: We hypothesized that 1) brain circuits involved in energy …

[HTML][HTML] Sweet but bitter: Focus on fructose impact on brain function in rodent models

MS Spagnuolo, S Iossa, L Cigliano - Nutrients, 2020 - mdpi.com
Fructose consumption has drastically increased during the last decades due to the extensive
commercial use of high-fructose corn syrup as a sweetener for beverages, snacks and …