Background Recent studies showed a link between a high fat diet (HFD)-induced obesity
and lipid accumulation in non-adipose tissues, such as skeletal muscle and liver, and insulin …

Aims/hypothesis Consuming a high-fat diet (HFD) induces insulin resistance in white
adipose tissue (WAT) within 1 week. However, little is known about the initiating events. One …

Saturated free fatty acids have been implicated in the increase of oxidative stress,
mitochondrial dysfunction, apoptosis, and insulin resistance seen in type 2 diabetes. The …

Background Although mounting evidence indicates that insulin resistance (IR) co‐occurs
with mitochondrial dysfunction in skeletal muscle, there is no clear causal link between …

Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and reduced
mitochondrial mass and function. We hypothesized a HFD may affect expression of genes …

Insulin resistance is a key pathophysiological feature of metabolic syndrome. However, the
initial events triggering the development of insulin resistance and its causal relations with …

Obesity and type 2 diabetes are associated with mitochondrial dysfunction in adipose tissue,
but the role for adipose tissue mitochondria in the development of these disorders is …

Low mitochondrial number and activity have been suggested as underlying factors in
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …

Although molecular approaches altering mitochondrial content have implied a direct
relationship between mitochondrial bioenergetics and insulin sensitivity, paradoxically …

High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a
major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction …