Endothelial cell (EC) senescence is increasingly recognized as a significant contributor to
the development of vascular dysfunction and age-related disorders and diseases, including …

Senescence compromises the essential role that the endothelium plays in maintaining
vascular homeostasis, so promoting endothelial dysfunction and the development of age …

In mammals, aging is associated with accumulation of senescent cells. Stresses such as
telomere shortening and reactive oxygen species induce “cellular senescence”, which is …

Cellular senescence is now recognised as one of the hallmarks of ageing. Herein, we
examine current findings on senescence of the vascular endothelium and its impacts on age …

Despite the decline in their proliferative potential, senescent cells display a high metabolic
activity. Senescent cells have been shown to acquire a more glycolytic state even in …

Endothelial cells are located at the crucial interface between circulating blood and semi-
solid tissues and have many important roles in maintaining systemic physiological function …

Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …

Endothelial cells (ECs) form the inner linings of blood vessels, and are directly exposed to
endogenous hazard signals and metabolites in the circulatory system. The senescence and …

Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related
vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known …

Aging is the main risk factor for cardiovascular diseases (CVD), and senescence in
endothelial cells seems to be an initial step in the cascade of events that will culminate with …