Cations regulate membrane attachment and functionality of DNA nanostructures

D Morzy, R Rubio-Sánchez, H Joshi… - Journal of the …, 2021 - ACS Publications
The interplay between nucleic acids and lipids underpins several key processes in
molecular biology, synthetic biotechnology, vaccine technology, and nanomedicine. These …

[HTML][HTML] Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

D Morzy, C Tekin, V Caroprese, R Rubio-Sánchez… - Nanoscale, 2023 - pubs.rsc.org
Nucleic acids and lipids function in close proximity in biological processes, as well as in
nanoengineered constructs for therapeutic applications. As both molecules carry a rich …

DNA nanostructures interacting with lipid bilayer membranes

M Langecker, V Arnaut, J List… - Accounts of chemical …, 2014 - ACS Publications
Conspectus DNA has been previously shown to be useful as a material for the fabrication of
static nanoscale objects, and also for the realization of dynamic molecular devices and …

DNA nanostructures in vitro, in vivo and on membranes

W Bae, S Kocabey, T Liedl - Nano Today, 2019 - Elsevier
Recent developments in DNA nanotechnology brought rich structural and functional
diversity. However, for DNA nanostructures to perform in a biologically relevant context …

Dynamic interactions between lipid-tethered DNA and phospholipid membranes

PM Arnott, H Joshi, A Aksimentiev, S Howorka - Langmuir, 2018 - ACS Publications
Lipid-anchored DNA can attach functional cargo to bilayer membranes in DNA
nanotechnology, synthetic biology, and cell biology research. To optimize DNA anchoring …

Controlling aggregation of cholesterol-modified DNA nanostructures

A Ohmann, K Göpfrich, H Joshi… - Nucleic acids …, 2019 - academic.oup.com
DNA nanotechnology allows for the design of programmable DNA-built nanodevices which
controllably interact with biological membranes and even mimic the function of natural …

[HTML][HTML] Emerging applications at the interface of DNA nanotechnology and cellular membranes: Perspectives from biology, engineering, and physics

W Wang, DS Arias, M Deserno, X Ren… - APL bioengineering, 2020 - pubs.aip.org
DNA nanotechnology has proven exceptionally apt at probing and manipulating biological
environments as it can create nanostructures of almost arbitrary shape that permit countless …

Binding of DNA to zwitterionic lipid layers mediated by divalent cations

DH Mengistu, K Bohinc, S May - The Journal of Physical Chemistry …, 2009 - ACS Publications
Divalent cations, ie, calcium, magnesium, and others, are able to enhance the ability of DNA
to interact with membranes that are composed of zwitterionic lipids such as …

Molecular mechanism of calcium-induced adsorption of DNA on zwitterionic phospholipid membranes

AY Antipina, AA Gurtovenko - The Journal of Physical Chemistry …, 2015 - ACS Publications
Interaction of DNA with zwitterionic phospholipids is an important long-standing problem in
the field of liposome-based gene delivery. Although it is well-established that divalent …

Polymorphism of DNA–anionic liposome complexes reveals hierarchy of ion-mediated interactions

H Liang, D Harries, GCL Wong - Proceedings of the …, 2005 - National Acad Sciences
Self-assembled DNA delivery systems based on anionic lipids (ALs) complexed with DNA
mediated by divalent cations have been recently introduced as an alternative to cationic lipid …