Anterior cruciate ligament (ACL) injury and meniscal tear (MT) are major causal factors for
developing post-traumatic osteoarthritis (PTOA), but the biological mechanism (s) are …

We have reported that anterior cruciate ligament (ACL) injury leads to the differential
dysregulation of the complement system in the synovium as compared to meniscus tear (MT) …

Introduction Patients with anterior cruciate ligament injury are at high risk of posttraumatic
osteoarthritis and their response to reconstructive surgery and rehabilitation vary. Proteins …

Background The complement system is suggested to be involved in the pathogenesis of
osteoarthritis (OA), and proinflammatory cytokines may play a role in OA development by …

Background Anterior cruciate ligament (ACL) and meniscus tears are common knee injuries.
Despite the high rate of post-traumatic osteoarthritis (PTOA) following these injuries, the …

Purpose Synovial inflammation in knee osteoarthritis (OA) causes disorganized synovial
angiogenesis and complement activation in synovial fluid, but links between complement …

Objective Increasing evidence has shown the involvement of the innate immune system and
inflammatory response in osteoarthritis (OA) pathogenesis; however, anterior cruciate …

Objective To investigate complement (C) factors (F) and their activation fragments
expression in OA joint tissues. Design Immunohistochemistry and quantitative imaging were …

The limited ability of articular cartilage to recover from injury, remains an unsolved clinical
challenge in orthopaedic surgery. Persistent injury of the articular surface can lead to the …

In conjunction with cartilage breakdown, muscle maladaptation including atrophy and
increased fibrosis have been observed in the quadriceps following anterior cruciate …