Sex, sex steroids, and diabetic cardiomyopathy: making the case for experimental focus

ME Reichelt, KM Mellor, JR Bell… - American Journal …, 2013 - journals.physiology.org
More than three decades ago, the Framingham study revealed that cardiovascular risk is
elevated for all diabetics and that this jeopardy is substantially accentuated for women in …

Cardiac health and diabetes mellitus in women: problems and prospects.

J Ren - Minerva cardioangiologica, 2006 - europepmc.org
Cardiovascular disease is the leading cause of morbidity and mortality in both genders.
Although premenopausal women display a lower prevalence in cardiovascular diseases …

Diabetic cardiomyopathy: do women differ from men?

J Ren, AF Ceylan-Isik - Endocrine, 2004 - Springer
Although many aspects of cardiovascular disease are similar between women and men, it is
becoming increasingly obvious that there are significant differences as well. Premenopausal …

[HTML][HTML] Sex differences of the diabetic heart

N Fourny, C Beauloye, M Bernard, S Horman… - Frontiers in …, 2021 - frontiersin.org
Type 2 diabetes is a chronic disease associated with micro-and macro-vascular
complications, including myocardial ischemia, and also with a specific and intrinsic cardiac …

[HTML][HTML] Diabetic cardiomyopathy: impact of biological sex on disease development and molecular signatures

R Toedebusch, A Belenchia, L Pulakat - Frontiers in physiology, 2018 - frontiersin.org
Diabetic cardiomyopathy refers to a unique set of heart-specific pathological variables
induced by hyperglycemia and insulin resistance. Given that cardiovascular disease (CVD) …

Understanding One Half of the Sex Difference Equation: The Modulatory Effects of Testosterone on Diabetic Cardiomyopathy

DE Venegas-Pino, GH Werstuck - The American Journal of Pathology, 2023 - Elsevier
Diabetes is a prevalent disease, primarily characterized by high blood sugar
(hyperglycemia). Significantly higher rates of myocardial dysfunction have been noted in …

Role of estrogen in type 1 and type 2 diabetes mellitus: a review of clinical and preclinical data

M De Paoli, GH Werstuck - Canadian journal of diabetes, 2020 - Elsevier
The incidence and prevalence of diabetes mellitus, and the cardiovascular complications
associated with this disease, are rapidly increasing worldwide. Individuals with diabetes …

Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia

C Chandramouli, ME Reichelt, CL Curl, U Varma… - Scientific reports, 2018 - nature.com
Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of
diastolic dysfunction. Increased cardiovascular risk associated with diabetes is more marked …

Sex differences in micro-and macro-vascular complications of diabetes mellitus

C Maric-Bilkan - Clinical Science, 2017 - portlandpress.com
Vascular complications are a leading cause of morbidity and mortality in both men and
women with type 1 (T1DM) or type 2 (T2DM) diabetes mellitus, however the prevalence …

Models of gender differences in cardiovascular disease

RD Patten - Drug Discovery Today: Disease Models, 2007 - Elsevier
Clinical observations made over several decades support the existence of gender
differences in cardiovascular disease prevalence and severity. For example, women exhibit …