Distinct from the traditional diagnostic/prognostic biomarker (adopted as the indicator of
disease state/process), the therapeutic biomarker (ThMAR) has emerged to be very crucial …

A biomarker is a biological observation that substitutes for and ideally predicts a clinically
relevant endpoint or intermediate outcome that is more difficult to observe. The use of …

Biomarkers enable the characterization of patient populations and quantitation of the extent
to which new drugs reach intended targets, alter proposed pathophysiological mechanisms …

Extensive efforts have been directed at the discovery, investigation and clinical monitoring of
targeted therapeutics. These efforts may be facilitated by the convenient access of the …

A number of proteins and nucleic acids have been explored as therapeutic targets. These
targets are subjects of interest in different areas of biomedical and pharmaceutical research …

In the future, biomarkers will play an increasingly important role in all phases of drug
development, including regulatory review. However, only a few of these biomarkers will …

Biomarker Tests for Molecularly Targeted Therapies — The Key to Unlocking Precision Medicine
| New England Journal of Medicine Skip to main content The New England Journal of Medicine …

Biomarkers of disease play an important role in medicine and have begun to assume a
greater role in drug discovery and development. The challenge for biomarkers is to allow …

Over the past 20 years, there has been an exponential increase in the number of
biomarkers. At the last count, there were 768,259 papers indexed in PubMed. gov directly …

With the availability of new technologies and the increased interest of medical practitioners
to use molecular biomarkers in early detection and diagnosis, and in the prediction of …