Many types of cancers, including endometrial cancer, were found to have cyclooxygenase-2
(COX-2) overexpression. Because this enzyme belongs to the group of pro-inflammatory …

Purpose Nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors
(COXibs) inhibit the progression of endometrial cancer, ovarian cancer and cervical cancer …

In recent years, the design of new antineoplastic agents that can halt the progression of
human malignancies with minimal systemic damage has been at the forefront of cancer …

Objective: Cyclooxygenase-2 (COX-2) is a critical enzyme associated with inflammation and
tumorigenesis. Although several studies have compared the expression of COX-2 in …

Objective: To examine effects of an inhibitor of cyclooxygenase (COX)-2, NS-398, on the
proliferation, apoptosis and invasion characteristics of endometrial cancer cell RL95-2 …

Background: Many experimental studies have demonstrated the importance of COX-2 in the
tumor angiogenesis. Inducible iNOS is responsible for a high and stable level of nitric oxide …

Abstract Aim: Endometrial cancer (EC), which is the most common gynecologic cancer,
develops as a result of disruption of the delicate balance between cell proliferation and cell …

The extracellular signal-regulated kinase kinase (MEK)/extracellular signal-regulated kinase
(ERK) pathway plays a critical role in the anticancer action in vitro. ERK1/2 activation or …

Endometrial cancer is one of the most common gynaecological malignancies worldwide.
Histologically, two types of endometrial cancer with morphological and molecular …

Endometriosis is an estrogen-dependent inflammatory disease, defined by the presence of
functional endometrial tissue outside of the uterine cavity. This disease is one of the main …