Mechanisms of PTEN loss in cancer: It's all about diversity
V Álvarez-Garcia, Y Tawil, HM Wise… - Seminars in cancer biology, 2019 - Elsevier
PTEN is a phosphatase which metabolises PIP 3, the lipid product of PI 3-Kinase, directly
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
opposing the activation of the oncogenic PI3K/AKT/mTOR signalling network. Accordingly …
PTEN function in normal and neoplastic growth
LML Chow, SJ Baker - Cancer letters, 2006 - Elsevier
The PTEN tumor suppressor is a central negative regulator of the PI3K/AKT signaling
cascade that influences multiple cellular functions including cell growth, survival …
cascade that influences multiple cellular functions including cell growth, survival …
[HTML][HTML] PTEN: multiple functions in human malignant tumors
M Milella, I Falcone, F Conciatori, U Cesta Incani… - Frontiers in …, 2015 - frontiersin.org
PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …
[HTML][HTML] Tenets of PTEN tumor suppression
Since its discovery as the elusive tumor suppressor gene at the frequently mutated 10q23
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
locus, PTEN has been identified as lost or mutated in several sporadic and heritable tumor …
PTEN: from pathology to biology
ML Sulis, R Parsons - Trends in cell biology, 2003 - cell.com
The PTEN tumour suppressor gene is mutated frequently in many malignancies and its
importance in the development of cancer is probably underestimated. As the primary …
importance in the development of cancer is probably underestimated. As the primary …
The functions and regulation of the PTEN tumour suppressor: new modes and prospects
PTEN is a potent tumour suppressor, and its loss of function is frequently observed in both
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
heritable and sporadic cancers. PTEN has phosphatase-dependent and phosphatase …
[HTML][HTML] Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization
JRM Yang, P Schiapparelli, HN Nguyen, A Igarashi… - Oncogene, 2017 - nature.com
PTEN is a PIP3 phosphatase that antagonizes oncogenic PI3-kinase signalling. Due to its
critical role in suppressing the potent signalling pathway, it is one of the most mutated …
critical role in suppressing the potent signalling pathway, it is one of the most mutated …
[PDF][PDF] The Biology and Clinical Relevance of the PTEN Tumor Suppressor Pathway
I Sansal, WR Sellers - Journal of clinical oncology, 2004 - researchgate.net
Genetic alterations targeting the PTEN tumor suppressor gene are among the most
frequently noted somatic mutations in human cancers. Such lesions have been noted in …
frequently noted somatic mutations in human cancers. Such lesions have been noted in …
PTEN function: how normal cells control it and tumour cells lose it
NR Leslie, CP Downes - Biochemical Journal, 2004 - portlandpress.com
The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …