Background & Aims Little is known about mechanisms of perineural invasion (PNI) by
pancreatic ductal adenocarcinomas (PDAs) or other tumors. Annexin A2 (ANXA2) regulates …

Pancreatic ductal adenocarcinoma (PDAC) metastasizes by neural, vascular, and local
invasion routes, which limit patient survival. In nerves and vessels, SLIT2 and its ROBO …

Solid cancers like pancreatic ductal adenocarcinoma (PDAC), a type of pancreatic cancer,
frequently exploit nerves for rapid dissemination. This neural invasion (NI) is an independent …

Purpose: Perineural invasion causes frequent local recurrence even after resection and a
poor prognosis for pancreatic cancer. We established perineural invasion models and …

Perineural invasion (PNI) is considered as an alternative route for the metastatic spread of
pancreatic cancer cells; however, the molecular changes leading to PNI are still poorly …

Tumor spread along nerves, a phenomenon known as perineurial invasion, is common in
various cancers including pancreatic ductal adenocarcinoma (PDAC). Neural invasion is …

The molecular mechanism of perineural invasion (PNI) is unclear, and insufficient detection
during early-stage PNI in vivo hampers its investigation. We aimed to identify a cytokine …

Neural alterations and aberrantly expressed nerve‐specific factors promoting tumor
progression are known to contribute to pancreatic cancer's extremely poor prognosis …

Background Perineural invasion (PNI) and autophagy are two common features in the tumor
microenvironment of pancreatic cancer (PanCa) and have a negative effect on prognosis …

Perineural invasion (PNI) occurs in most pancreatic ductal adenocarcinomas (PDACs). The
relationship between cancer cells and peripheral nerves, however, is unknown. Therefore …