The role of microneedle arrays in drug delivery and patient monitoring to prevent diabetes induced fibrosis

E McAlister, M Kirkby, J Dominguez-Robles… - Advanced Drug Delivery …, 2021 - Elsevier
Diabetes affects approximately 450 million adults globally. If not effectively managed,
chronic hyperglycaemia causes tissue damage that can develop into fibrosis. Fibrosis leads …

Microneedle-based insulin transdermal delivery system: current status and translation challenges

J Zhao, G Xu, X Yao, H Zhou, B Lyu, S Pei… - Drug Delivery and …, 2022 - Springer
Diabetes mellitus is a metabolic disease manifested by hyperglycemia. For patients with
type 1 and advanced type 2 diabetes mellitus, insulin therapy is essential. Subcutaneous …

Glucose-responsive microneedle patches for diabetes treatment

G Chen, J Yu, Z Gu - Journal of diabetes science and …, 2019 - journals.sagepub.com
Antidiabetic therapeutics, including insulin as well as glucagon-like peptide 1 (GLP-1) and
its analogs, are essential for people with diabetes to regulate their blood glucose levels …

Microneedle–Future prospect for efficient drug delivery in diabetes management

BA Jana, AD Wadhwani - Indian journal of pharmacology, 2019 - journals.lww.com
This review aims at focusing on the use of microneedles (MNs) as an emerging novel drug
delivery carrier for an effective treatment in diabetic patients. There are many limitations in …

[HTML][HTML] The clinical and translational prospects of microneedle devices, with a focus on insulin therapy for diabetes mellitus as a case study

F Smith, AH Sabri, M Heppel, I Fonseca… - International journal of …, 2022 - Elsevier
Microneedles have the clinical advantage of being able to deliver complex drugs across the
skin in a convenient and comfortable manner yet haven't successfully transitioned to medical …

Microneedles for transdermal delivery of insulin

S Xie, Z Li, Z Yu - Journal of Drug Delivery Science and Technology, 2015 - Elsevier
Insulin medication is currently effective in the treatment of type I diabetes. Due to the poor
absorption or enzymatic degradation of insulin in the gastrointestinal tract and liver, the …

Insulin delivery systems combined with microneedle technology

X Jin, DD Zhu, BZ Chen, M Ashfaq, XD Guo - Advanced drug delivery …, 2018 - Elsevier
Diabetes, a metabolic disorder of glucose, is a serious chronic disease and an important
public health problem. Insulin is one of the hormones for modulating blood glucose level …

Biodegradable polymeric insulin microneedles–a design and materials perspective review

M Starlin Chellathurai, S Mahmood… - Drug Delivery, 2024 - Taylor & Francis
Microneedle (MN) delivery devices are more accepted by people than regular traditional
needle injections (eg vaccination) due to their simplicity and adaptability. Thus, patients of …

Transdermal delivery of insulin via microneedles

RJ Narayan - Journal of Biomedical Nanotechnology, 2014 - ingentaconnect.com
Treatment of insulin-dependent diabetes mellitus, also known as Type 1 diabetes mellitus,
requires delivery of exogenous insulin via injection or pump. An alternative to syringe-based …

A pilot study in humans of microneedle sensor arrays for continuous glucose monitoring

S Sharma, A El-Laboudi, M Reddy, N Jugnee… - Analytical …, 2018 - pubs.rsc.org
Although subcutaneously implanted continuous glucose monitoring (CGM) devices have
been shown to support diabetes self-management, their uptake remains low due to a …