Pancreatic cancer is one of the major malignancies and causes of mortality worldwide. E3
ubiquitin–protein ligases transfer activated ubiquitin from ubiquitin-conjugating enzymes to …

F-box and WD repeat domain-containing 7 (FBW7) is the substrate recognition component
of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex and functions as a major tumor …

Despite improvements in surgical procedures and comprehensive therapies, pancreatic
cancer remains one of the most aggressive and deadly human malignancies. It is therefore …

Krüppel-like factor 4 (KLF4, GKLF) is a zinc-finger transcription factor involved in a large
variety of cellular processes, including apoptosis, cell cycle progression, as well as stem cell …

Krüppel‐like factor 4 (KLF4) is a zinc‐finger containing DNA‐binding transcription factor
involved in tumorigenesis and acts as a tumour suppressor or an oncogene depending on …

Background The ubiquitin-proteasome system participates in the pathogenesis and
progression of hepatocellular carcinoma (HCC). As an E3 ubiquitin ligase, RNF128 has …

KLF4 is implicated in tumor progression of pancreatic cancer, but the molecular regulatory
mechanism of KLF4 needs to be further specified. We aimed to probe molecular regulatory …

Purpose The long noncoding RNA LINC00261 was reported to be involved in
carcinogenesis and has been validated as a tumor suppressor in pancreatic cancer (PC); …

Abstract Background The transcription factor Krüppel-like factor 8 (KLF8) plays an important
role in tumor development and growth, but its role in pancreatic cancer (PC) is not clear …

KLF10 is now classified as a member of the Krüppel-like transcription factor family and acts
as a tumor suppressor. Although KLF10 is originally named as TGF-β-inducible early gene-1 …