Much of the mechanism by which Wnt signaling drives proliferation during oncogenesis is
attributed to its regulation of the cell cycle. Here, we show how Wnt/β‐catenin signaling …

WNT signaling was discovered in tumor models and has been recognized as a regulator of
cancer development and progression for over 3 decades. Recent work has highlighted a …

Background There is increasing evidence that oncogenic Wnt signaling directs metabolic
reprogramming of cancer cells to favor aerobic glycolysis or Warburg metabolism. In colon …

Aerobic glycolysis, also known as the Warburg effect, is a hallmark of cancerous tissues.
Despite its importance in cancer development, our understanding of mechanisms driving …

At the cellular level, the biological processes of cell proliferation, growth arrest,
differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic …

Simple Summary The canonical WNT/β-catenin pathway is upregulated in cancers and
plays a major role in proliferation, invasion, apoptosis and angiogenesis. Recent studies …

Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about
how metabolic reprogramming contributes to early stages of transformation. Here, we show …

Previously, we proposed a new model for understanding the Warburg effect in
tumorigenesis and metastasis. In this model, the stromal fibroblasts would undergo aerobic …

Background Two recent observations regarding the Warburg effect are that (i) the
metabolism of stem cells is constitutive (aerobic) glycolysis while normal cellular …

Post-translational modification (PTM) is an important step of signal transduction that
transfers chemical groups such as phosphate, acetyl and glycosyl groups from one protein …