[PDF][PDF] MAIT cells are enriched and highly functional in ascites of patients with decompensated liver cirrhosis

CE Niehaus, B Strunz, M Cornillet, CS Falk… - …, 2020 - Wiley Online Library
Background and Aims Patients with advanced liver cirrhosis have an increased
susceptibility to infections. As part of the cirrhosis‐associated immune dysfunction, mucosal …

[HTML][HTML] Mucosal-associated invariant T cells redistribute to the peritoneal cavity during spontaneous bacterial peritonitis and contribute to peritoneal inflammation

O Ibidapo-Obe, S Stengel, N Köse-Vogel… - Cellular and molecular …, 2020 - Elsevier
Background & Aims Mucosal-associated invariant T (MAIT) cells are depleted from blood in
patients with advanced liver disease and show features of immune dysfunction. Because …

Modeling the hepatology workforce in the United States: a predicted critical shortage

MW Russo, OK Fix, AA Koteish, K Duggan… - Hepatology, 2020 - journals.lww.com
Conclusions Despite severely diminished MAIT cell numbers and impaired phenotype in
circulation, peritoneal MAIT cells remain abundant, activated, and highly functional in …

MAIT cells: new guardians of the liver

A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …

Mucosal-associated invariant T cells in chronic inflammatory liver disease

FJ Bolte, B Rehermann - Seminars in liver disease, 2018 - thieme-connect.com
The broadening field of microbiome research has led to a substantial reappraisal of the gut–
liver axis and its role in chronic liver disease. The liver is a central immunologic organ that is …

[HTML][HTML] Mucosal-associated invariant T cells in hepatitis B virus-related liver failure

H Xue, H Li, LL Ju, XD Han, TC Cheng… - World journal of …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Liver failure has high mortality and poor prognosis, and establishing new
reliable markers for predicting its prognosis is necessary. Mucosal-associated invariant T …

MAIT cells in liver inflammation and fibrosis

H Mehta, MJ Lett, P Klenerman… - Seminars in …, 2022 - Springer
Mucosal-associated invariant T cells or MAIT cells are an abundant cell type in humans and
especially so in the liver. MAIT cells are a subset of T lymphocytes that sit at a bridge …

[PDF][PDF] MAIT cells are chronically activated in patients with autoimmune liver disease and promote profibrogenic hepatic stellate cell activation

K Böttcher, K Rombouts, F Saffioti, D Roccarina… - …, 2018 - Wiley Online Library
Autoimmune liver diseases (AILDs) are chronic liver pathologies characterized by fibrosis
and cirrhosis due to immune‐mediated liver damage. In this study, we addressed the …

Lights on MAIT cells, a new immune player in liver diseases

A Toubal, A Lehuen - Journal of Hepatology, 2016 - journal-of-hepatology.eu
Mucosal associated invariant T (MAIT) cells are a recently identified subset of invariant T
cells. They express a conserved invariant T cell antigen receptor (TCR) a-chain, composed …

Persistent deficiency of mucosa-associated invariant T (MAIT) cells during alcohol-related liver disease

Y Zhang, Y Fan, W He, Y Han, H Bao, R Yang, B Wang… - Cell & Bioscience, 2021 - Springer
Background Alcohol-related liver disease (ALD) is a major cause of chronic liver diseases.
Inflammatory response is a basic pathological feature of ALD. Mucosal-associated invariant …