Overgrowth syndromes are a heterogeneous group of rare disorders characterized by
generalized or segmental excessive growth commonly associated with additional features …

Abnormally excessive growth results from perturbation of a complex interplay of genetic,
epigenetic, and hormonal factors that orchestrate human growth. Overgrowth syndromes …

Overgrowth syndromes (OGS) comprise a heterogeneous group of disorders in which the
main characteristic is that either weight, height, or head circumference is 2–3 standard …

The overgrowth syndromes are important to diagnose, not just for accurate genetic
counseling, but also for knowledge surrounding cancer surveillance and prognosis. There …

Human overgrowth disorders are characterized by excessive prenatal and/or postnatal
growth of various tissues. These disorders often present with tall stature, macrocephaly …

New discoveries continue to be made regarding the genetic basis for many overgrowth
syndromes and the development of a much needed molecular classification system for …

The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

ABSTRACT A striking feature of the overgrowth syndromes (OGS) is the risk of cancer. In
some OGS (Beckwith-Wiedemann, Perlman, Simpson-Golabi-Behmel syndromes and …

Although problems in overgrowth were documented and appreciated in the nineteenth
century, conditions such as Beckwith–Wiedemannsyndrome (BWS, OMIM 130650) and …

Although problems in overgrowth were documented and appreciated in the 19th century and
conditions such as the Beckwith-Wiedemann, Sotos, and other syndromes were delineated …