Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …

Tissue-resident memory (T RM) T cells are distinct population of non-circulating lymphocytes
that play an important role in mediating regional immunity. T RM-like cells have now been …

Immune responses in tissues are constrained by the physiological properties of the tissue
involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T …

CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic
approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A …

Following their activation and expansion in response to foreign threats, many T cells are
retained in peripheral tissues without recirculating in the blood. These tissue-resident CD8+ …

Resident memory (TRM) cells are a distinct tissue-localized T cell lineage that is crucial for
protective immunity in peripheral tissues. While a great deal of effort has focused on defining …

Long-lived memory CD8+ T cells play important roles in tumor immunity. Studies over the
past two decades have identified four subsets of memory CD8+ T cells-central, effector, stem …

The prognostic significance of tumor-infiltrating lymphocytes (TILs) has been a longstanding
topic of debate. In cases where TILs have improved patient outcome, T lymphocytes are …

Memory T cells can be generated and remain long-term in different tissues following
infection or immunization. Tissue-resident memory T (T RM) cells are a unique group of …

Tissue-resident memory T cells (TRM) represent a heterogeneous T cell population with the
functionality of both effector and memory T cells. TRM express residence gene signatures …