Many studies have demonstrated the involvement of proteases in gut physiology and
pathophysiology over the recent years. Among them, thrombin has appeared for a long time …

Abstract Background and Aims Thrombin levels in the colon of Crohn's disease patients
have recently been found to be elevated 100-fold compared with healthy controls. Our aim …

Inflammation and coagulation constitute two host defence systems with complementary
physiological roles in limiting tissue damage, restoring homeostasis and eliminating …

Thrombin is a serine protease involved in many physiological functions and its receptor, the
protease-activated receptor-1 (PAR-1), has a wide tissue distribution. We hypothesized that …

Recent evidence implicating tissue factor and the protein C pathway in the hypercoagulable
state associated with intestinal inflammation suggests that thrombin is likely to contribute to …

Thrombin, a key “final common pathway” coagulation cascade proteinase, can be
envisioned as one of the body's main “sentries,” always on the lookout to be rendered active …

The thrombin receptor, protease-activated receptor-1 (PAR-1), has wide tissue distribution
and is involved in many physiological functions. Because thrombin is in the intestinal lumen …

Thrombin is a multifunctional serine protease produced from prothrombin, and is a key
regulator in hemostatic and non‐hemostatic processes. It is the main effector protease in …

Hemostasis and immune responses are evolutionarily and functionally related systems on
the coordinated work of which vital processes—protection from pathogens and blood loss …

CXC chemokines, including human interleukin-8 and rat cytokine-induced neutrophil
chemoattractant-1, play a crucial role in the pathogenesis of intestinal inflammation induced …