Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Within a tumor, IL-1β is produced and secreted by various cell types, such as immune cells,
fibroblasts, or cancer cells. The IL1B gene is induced after “priming” of the cells and a …

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …

Interleukin-1 (IL-1) is a major “alarm” upstream pro-inflammatory cytokine that also affects
immunity and hematopoiesis by inducing cytokine cascades. In the tumor arena, IL-1 is …

The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells
which produce cytokines, growth factors, and adhesion molecules that promote tumor …

Abstract Interleukin-1 (IL-1) includes a family of closely related genes; the two major
agonistic proteins, IL-1α and IL-1β, are pleiotropic and affect mainly inflammation, immunity …

In this study, we assessed the involvement of IL-1β in early angiogenic responses induced
by malignant cells using Matrigel plugs supplemented with B16 melanoma cells. We found …

Summary Interleukin-1 (IL-1) is a key orchestrator of inflammation and plays an important
role in tumor progression. Based on preclinical models and human genetic associations, we …

Interleukin-1α (IL-1α) is a major alarmin cytokine which triggers and boosts the inflammatory
responses. Since its discovery in the 1940s, the structure and bioactivity of IL-1α has been …

Inflammation is an important component of the tumor microenvironment. IL‐1 is an
inflammatory cytokine which plays a key role in carcinogenesis and tumor progression. IL‐1 …