Although pneumococcal conjugate vaccines are close to being licensed, a more profound
knowledge of the virulence factors responsible for the morbidity and mortality caused by …

The principal virulence determinant of most encapsulated bacterial pathogens is the
possession of an extracellular capsule. This paper discusses biological aspects of the …

The overall goal for this review is to summarize the current body of knowledge about the
structure and function of major known antigens of Streptococcus pneumoniae, a major gram …

Various aspects of the host's response to infection by Streptococcus pneumoniae are
reviewed. First, the structure of the bacterium is described, with a focus on those elements …

Infections with Streptococcus pneumoniae continue to cause significant morbidity and
mortality in humans, despite the availability of effective antibiotic therapy and of a …

Streptococcus pneumoniae is a causative agent for community acquired pneumonia,
bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant …

Streptococcus pneumoniae is a human pathogen causing pneumoniae, bacterimia and
meningitis and its virulence is due to a structurally distinct capsular polysaccharide …

Streptococcus pneumoniae causes significant morbidity and mortality. Children younger
than 2 years and individuals older than 65 years experience the highest rates of …

The pathogenesis of bacterial infection involves a series of interactions between the
virulence determinants of the microorganisms and the immunity of the host. Studies on the …

Streptococcus pneumoniae (the pneumococcus) is an important human pathogen. Its
virulence is largely due to its polysaccharide capsule, which shields it from the host immune …