As outlined in the “International Guidelines for Management of Sepsis and Septic Shock:
2016,” initial fluid resuscitation and administration of antibiotics are key steps in the early …

Background Pre-clinical animal studies precede the majority of clinical trials. While the
clinical definitions of sepsis and recommended treatments are regularly updated, a …

Preclinical animal studies are mandatory before new treatments can be tested in clinical
trials. However, their use in developing new therapies for sepsis has been controversial …

Although the clinical definitions of sepsis and recommended treatments are regularly
updated, a systematic review has not been done for preclinical models. To address this …

International Guideless for Management of Severe Sepsis and Septic Shock was recently
published (February 2013) in Critical Care Medicine and Intensive Care Medicine. 1, 2 The …

Sepsis is a clinical syndrome encompassing physiologic and biological abnormalities
caused by a dysregulated host response to infection. Sepsis progression into septic shock is …

To effectively improve outcomes of septic patients, we first need to elucidate the multifaceted
pathogenesis of sepsis syndromes and related inflammatory conditions. In fulfillment of such …

Sepsis is responsible for tremendous morbidity, mortality and health-care expenditure
worldwide. Over the past decade, the conceptualization of sepsis has shifted from one …

ABSTRACT INTRODUCTION Fluid therapy is one of the cornerstones of initial management
of sepsis, but the choice of fluids used for resuscitation is controversial. OBJECTIVES While …

Sepsis remains a major cause of morbidity and mortality mainly because of sepsis-induced
multiple organ dysfunction. In contrast to preclinical studies, most clinical trials of promising …