Phenotypic variation in skeletal traits and diseases is the product of genetic and
environmental factors. Epigenetic mechanisms include information‐containing factors, other …

The purpose of this narrative review is to provide an overview of last year's publications in
the field of genetics, genomics and epigenetics in the osteoarthritis (OA) field. Major themes …

Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …

Objective In this review, we have highlighted the advances over the past year in genetics,
genomics and epigenetics in the field of osteoarthritis (OA). Methods A literature search of …

Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …

Epigenetics refers to the study of mechanisms able to influence gene expression in a stable
and potentially heritable manner without altering the DNA sequence. These mechanisms …

Bone is a specialized connective tissue with a calcified extracellular matrix in which cells are
embedded. Besides providing the internal support of the body and protection for vital …

Osteoarthritis (OA) is a common complex disease of high public health burden. OA is
characterized by the degeneration of affected joints leading to pain and reduced mobility …

Rapid advancements in the field of genomics, enabled by the achievements of the Human
Genome Project and the complete decoding of the human genome, have opened an …

Osteoarticular diseases, such as arthritis or osteoarthritis, are multifactorial diseases with an
underlying genetic etiology that are challenging to study. Genome-Wide Association studies …