Aging is accompanied by reduced remodeling of skeletal muscle extracellular matrix (ECM),
which is exacerbated during recovery following periods of disuse atrophy. Mechanotherapy …

Age‐related declines in skeletal muscle regeneration have been attributed to muscle stem
cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading to fibrosis …

Background Skeletal muscle aging is associated with a decreased regenerative potential
due to the loss of function of endogenous stem cells or myogenic progenitor cells (MPCs) …

Aged skeletal muscle is characterized by poor muscle recovery following disuse coinciding
with an impaired muscle pro‐inflammatory macrophage response. Macrophage …

Skeletal muscle regeneration is driven by the interaction of myogenic and non-myogenic
cells. In aging, regeneration is impaired due to dysfunctions of myogenic and non-myogenic …

During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …

We are living longer, but our healthspan has not increased. The goal of regenerative
medicine is to increase quality of life through an understanding of the cellular and molecular …

The skeletal muscle is a dynamic organ composed of contractile muscle fibers, connective
tissues, blood vessels and nerve endings. Its main function is to provide motility to the body …

An individual skeletal muscle is a complex structure, composed of large contractile
myofibers, connective tissue, nerve tissue, immune cells, stem cells and the vasculature …

Highlights•Muscle stem cell function loss contributes to reduced strength in old age.•Single
cell technologies reveal exciting details of muscle biology during aging.•Muscle Cellular …