Dopaminergic neurons in the substantia nigra (SN) expressing SUR1/Kir6. 2 type ATP-
sensitive potassium channels (K-ATP) are more vulnerable to rotenone or metabolic stress …

Parkinson's disease (PD) is a progressive neurodegenerative disorder, for which there are
no effective disease-modifying therapies. Growing evidence from studies in human PD …

Background Two active compounds, baicalein and its glycoside baicalin were found in the
dried root of Scutellaria baicalensis Georgi, and reported to be neuroprotective in vitro and …

This study is to investigate the effect of baicalin (BL) against oxidative injury stress of SH-
SY5Y cells induced by H2O2 and the possible mechanism. SH-SY5Y cells were pre …

Mounting evidence reveals that ATP‐sensitive potassium (KATP) channel openers (KCOs)
exert significant neuroprotection in vivo and in vitro in several models of Parkinson's disease …

In the present study, we first investigated the effects of unilateral 6-hydroxydopamine (6-
OHDA) lesioning of the substantia nigra pars compacta (SNc) on the expression of subunits …

Parkinson's disease is characterized by an extensive loss of dopaminergic neurons in the
substantia nigra pars compacta. The final common pathway in the demise of these cells may …

Tetrahydroberberine (THB) exhibits neuroprotective effects but its targets and underlying
mechanisms are largely unknown. Emerging evidence indicates that ATP-sensitive …

Oxidative stress is implicated in the etiology of Parkinson's disease (PD), the second most
common neurodegenerative disease. PD is treated with chronic administration of l-3, 4 …

Accumulating evidence suggests that ATP‐sensitive potassium (KATP) channels play an
important role in the selective degeneration of dopaminergic neurons in the substantia nigra …