Infection Dynamics of Hepatitis E Virus in Wild-Type and Immunoglobulin Heavy Chain Knockout JH−/− Gnotobiotic Piglets

DM Yugo, CL Heffron, J Ryu, K Uh… - Journal of …, 2018 - Am Soc Microbiol
Hepatitis E virus (HEV), the causative agent of hepatitis E, is an important but incompletely
understood pathogen causing high mortality during pregnancy and leading to chronic …

Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model

TPE Williams, C Kasorndorkbua… - Journal of clinical …, 2001 - Am Soc Microbiol
Hepatitis E virus (HEV) is the major cause of enterically transmitted non-A, non-B hepatitis in
many developing countries and is also endemic in many industrialized countries. Due to the …

Cross-species transmission and histopathological variation in specific-pathogen-free minipigs infected with different hepatitis E virus strains

S Jung, D Yeo, DJ Seo, IS Choi, C Choi - Veterinary Research, 2024 - Springer
Hepatitis E virus (HEV) is a major cause of viral hepatitis worldwide. Pigs are the natural
host of HEV genotype 3 and the main reservoir of HEV. As the host range of HEV genotype 3 …

Rat hepatitis E virus (HEV) cross-species infection and transmission in pigs

KK Yadav, PA Boley, CM Lee, S Khatiwada, K Jung… - bioRxiv, 2023 - biorxiv.org
Rocahepevirus ratti, an emerging hepatitis E virus (HEV), has recently been found to be
infectious to humans. Rats are a primary reservoir of the virus; thus, it is referred to as rat …

Experimental infection of rabbits with rabbit and genotypes 1 and 4 hepatitis E viruses

H Ma, L Zheng, Y Liu, C Zhao, TJ Harrison, Y Ma… - PLoS one, 2010 - journals.plos.org
Background A recent study provided evidence that farmed rabbits in China harbor a novel
hepatitis E virus (HEV) genotype. Although the rabbit HEV isolate had 77–79% nucleotide …

SPF rabbits infected with rabbit hepatitis E virus isolate experimentally showing the chronicity of hepatitis

J Han, Y Lei, L Liu, P Liu, J Xia, Y Zhang, H Zeng… - PLoS …, 2014 - journals.plos.org
This study focused on investigating the pathogenesis seen in specific-pathogen-free (SPF)
rabbits following infection with a homologous rabbit HEV isolate (CHN-BJ-rb14) and …

Detection of genotype 4 swine hepatitis E virus in systemic tissues in cross-species infected rabbits

Q Wu, J An, R She, R Shi, W Hao, MH Soomro… - PLoS …, 2017 - journals.plos.org
Increasing evidence demonstrates that hepatitis E virus (HEV) can be transmitted across
species. According to previous reports, swine HEV has two genotypes, genotype 3 and 4 …

Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 …

BJ Sanford, BA Dryman, YW Huang, AR Feagins… - Virus research, 2011 - Elsevier
Hepatitis E virus (HEV) is an important human pathogen. At least four recognized and two
putative genotypes of mammalian HEV have been reported: genotypes 1 and 2 are …

Successful infection of BALB/c mice by a swine hepatitis E virus clone constructed with reverse genetics

W Yu, C Yang, X Hao, T Ma, F Huang - BMC infectious diseases, 2018 - Springer
Abstract Background Hepatitis E virus (HEV) is a leading cause of hepatitis worldwide.
However, its infection biology and pathogenesis remain largely elusive. Furthermore, no …

Different outcomes of experimental hepatitis E virus infection in diverse mouse strains, Wistar rats, and rabbits

J Schlosser, L Dähnert, P Dremsek, K Tauscher, C Fast… - Viruses, 2018 - mdpi.com
Hepatitis E virus (HEV) is the causative agent of acute hepatitis E in humans in developing
countries, but autochthonous cases of zoonotic genotype 3 (HEV-3) infection also occur in …