Immunosenescence and human vaccine immune responses
SN Crooke, IG Ovsyannikova, GA Poland… - Immunity & …, 2019 - Springer
The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …
“immunosenescence”—has been generally associated with an increased susceptibility to …
Understanding immunosenescence and its impact on vaccination of older adults
JC Allen, FR Toapanta, W Chen, SM Tennant - Vaccine, 2020 - Elsevier
Older adults are more susceptible to viral and bacterial infection, and experience higher
incidence and severity of infectious diseases. Although vaccination is the most logical …
incidence and severity of infectious diseases. Although vaccination is the most logical …
Age-related decline in immunity: implications for vaccine responsiveness
R Kumar, EA Burns - Expert review of vaccines, 2008 - Taylor & Francis
Aging is associated with declines in immune system function, or 'immunosenescence',
leading to progressive deterioration in both innate and adaptive immunity. These changes …
leading to progressive deterioration in both innate and adaptive immunity. These changes …
Vaccination in the elderly: an immunological perspective
WH Chen, BF Kozlovsky, RB Effros… - Trends in …, 2009 - cell.com
Successful vaccination of the elderly against important infectious pathogens that cause high
morbidity and mortality represents a growing public health priority. Building on the theme of …
morbidity and mortality represents a growing public health priority. Building on the theme of …
Immunosenescence: what does it mean to health outcomes in older adults?
JE McElhaney, RB Effros - Current opinion in immunology, 2009 - Elsevier
The most profound consequences of immune senescence with respect to human health are
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …
the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes …
Understanding immunosenescence to improve responses to vaccines
JJ Goronzy, CM Weyand - Nature immunology, 2013 - nature.com
In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …
because of the adaptive immune system's inability to generate protective immunity. The age …
Immunosenescence: A systems-level overview of immune cell biology and strategies for improving vaccine responses
SN Crooke, IG Ovsyannikova, GA Poland… - Experimental …, 2019 - Elsevier
Immunosenescence contributes to a decreased capacity of the immune system to respond
effectively to infections or vaccines in the elderly. The full extent of the biological changes …
effectively to infections or vaccines in the elderly. The full extent of the biological changes …
Aging and options to halt declining immunity to virus infections
MÁ Palacios-Pedrero, ADME Osterhaus… - Frontiers in …, 2021 - frontiersin.org
Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …
The effect of aging of the immune system on vaccination responses
JM Lord - Human vaccines & immunotherapeutics, 2013 - Taylor & Francis
With a falling birth rate and increasing life expectancy we are experiencing dramatic
demographic changes that result in an ever ageing population. Aging is accompanied by …
demographic changes that result in an ever ageing population. Aging is accompanied by …
Targeting inflammation and immunosenescence to improve vaccine responses in the elderly
B Pereira, XN Xu, AN Akbar - Frontiers in immunology, 2020 - frontiersin.org
One of the most appreciated consequences of immunosenescence is an impaired response
to vaccines with advanced age. While most studies report impaired antibody responses in …
to vaccines with advanced age. While most studies report impaired antibody responses in …