Identification of druggable inhibitory immune checkpoints on Natural Killer cells in COVID-19

O Demaria, J Carvelli, L Batista, ML Thibult… - Cellular & molecular …, 2020 - nature.com
Infection with SARS-COV-2 is the cause of COVID-19 and has generated an unprecedented
health crisis worldwide. While most of the patients experience mild symptoms, around 20 …

Flattening the COVID-19 curve with natural killer cell based immunotherapies

M Market, L Angka, AB Martel, D Bastin… - Frontiers in …, 2020 - frontiersin.org
Natural Killer (NK) cells are innate immune responders critical for viral clearance and
immunomodulation. Despite their vital role in viral infection, the contribution of NK cells in …

NK cell dysfunction in patients with COVID-19

J Bi - Cellular & molecular immunology, 2022 - nature.com
A substantial proportion of patients with coronavirus disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection might develop …

Defining the role of natural killer cells in COVID-19

MJ Lee, CA Blish - Nature immunology, 2023 - nature.com
Natural killer (NK) cells are critical effectors of antiviral immunity. Researchers have
therefore sought to characterize the NK cell response to coronavirus disease 2019 (COVID …

Abnormality in the NK-cell population is prolonged in severe COVID-19 patients

G Leem, S Cheon, H Lee, SJ Choi, S Jeong… - Journal of Allergy and …, 2021 - Elsevier
Background Our understanding of adaptive immune responses in patients with coronavirus
disease 2019 (COVID-19) is rapidly evolving, but information on the innate immune …

Exploring the utility of NK cells in COVID-19

X Deng, H Terunuma, M Nieda - Biomedicines, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) can manifest as acute respiratory distress syndrome
and is associated with substantial morbidity and mortality. Extensive data now indicate that …

Natural killer cell immunotypes related to COVID-19 disease severity

C Maucourant, I Filipovic, A Ponzetta, S Aleman… - Science …, 2020 - science.org
Understanding innate immune responses in coronavirus disease 2019 (COVID-19) is
important to decipher mechanisms of host responses and interpret disease pathogenesis …

Siglec-9 restrains antibody-dependent natural killer cell cytotoxicity against SARS-CoV-2

P Saini, OS Adeniji, D Bordoloi, J Kinslow, J Martinson… - MBio, 2023 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alters the
immunological profiles of natural killer (NK) cells. However, whether NK antiviral functions …

SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis

M Lenart, M Górecka, M Bochenek… - Frontiers in …, 2023 - frontiersin.org
Introduction Natural killer (NK) cells plays a pivotal role in the control of viral infections, and
their function depend on the balance between their activating and inhibitory receptors. The …

Functional exhaustion of antiviral lymphocytes in COVID-19 patients

M Zheng, Y Gao, G Wang, G Song, S Liu… - Cellular & molecular …, 2020 - nature.com
In December 2019, a novel coronavirus was first reported in Wuhan, China. 1 It was named
by the World Health Organization as severe acute respiratory syndrome coronavirus 2 …