Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography

EHL Chen, CH Wang, YT Liao, FY Chan… - Nature …, 2023 - nature.com
The abuse of antibiotics has led to the emergence of multidrug-resistant microbial
pathogens, presenting a pressing challenge in global healthcare. Membrane-disrupting …

A how-to guide for mode of action analysis of antimicrobial peptides

AB Schäfer, M Wenzel - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Antimicrobial peptides (AMPs) are a promising alternative to classical antibiotics in the fight
against multi-resistant bacteria. They are produced by organisms from all domains of life and …

Aggregated amphiphilic antimicrobial peptides embedded in bacterial membranes

H Gong, M Liao, X Hu, K Fa, S Phanphak… - … applied materials & …, 2020 - ACS Publications
Molecular dynamics (MD) simulations, stochastic optical reconstruction microscopy
(STORM), and neutron reflection (NR) were combined to explore how antimicrobial peptides …

Mode-of-action of antimicrobial peptides: membrane disruption vs. intracellular mechanisms

AH Benfield, ST Henriques - Frontiers in Medical Technology, 2020 - frontiersin.org
Antimicrobial peptides are an attractive alternative to traditional antibiotics, due to their
physicochemical properties, activity toward a broad spectrum of bacteria, and mode-of …

Imaging the action of antimicrobial peptides on living bacterial cells

ML Gee, M Burton, A Grevis-James, MA Hossain… - Scientific reports, 2013 - nature.com
Antimicrobial peptides hold promise as broad-spectrum alternatives to conventional
antibiotics. The mechanism of action of this class of peptide is a topical area of research …

Membrane active antimicrobial peptides: translating mechanistic insights to design

J Li, JJ Koh, S Liu, R Lakshminarayanan… - Frontiers in …, 2017 - frontiersin.org
Antimicrobial peptides (AMPs) are promising next generation antibiotics that hold great
potential for combating bacterial resistance. AMPs can be both bacteriostatic and …

Intracellular biomass flocculation as a key mechanism of rapid bacterial killing by cationic, amphipathic antimicrobial peptides and peptoids

NP Chongsiriwatana, JS Lin, R Kapoor, M Wetzler… - Scientific reports, 2017 - nature.com
Many organisms rely on antimicrobial peptides (AMPs) as a first line of defense against
pathogens. In general, most AMPs are thought to kill bacteria by binding to and disrupting …

Self-assembled peptide nanofibers display natural antimicrobial peptides to selectively kill bacteria without compromising cytocompatibility

W Chen, S Yang, S Li, JC Lang, C Mao… - … applied materials & …, 2019 - ACS Publications
One of the major hurdles in the development of antimicrobial peptide (AMP)-based materials
is their poor capacity in selectively killing bacteria without harming nearby mammalian cells …

Antimicrobial peptides: to membranes and beyond

JF Marcos, M Gandía - Expert Opinion on Drug Discovery, 2009 - Taylor & Francis
Background: Antimicrobial peptides (AMP) are widely recognized as promising alternatives
to the current use of antibiotics and fungicides. Amino-acid sequences of a vast majority of …

Simulations of membrane-disrupting peptides II: AMP piscidin 1 favors surface defects over pores

BS Perrin, R Fu, ML Cotten, RW Pastor - Biophysical journal, 2016 - cell.com
Antimicrobial peptides (AMPs) that disrupt bacterial membranes are promising therapeutics
against the growing number of antibiotic-resistant bacteria. The mechanism of membrane …