Since the development of chemical neuroanatomical tools in the 1960s, a tremendous
wealth of information has been generated on the anatomical components of the serotonergic …

The prefrontal cortex (PFC) is enriched in several serotonin receptors, including 5-HT1A-R,
5-HT2A-R, and 5-HT3-R. These receptors modulate PFC activity due to their expression in …

Abstract Serotonergic 5-HT1A and 5-HT2A receptors are abundantly expressed in prefrontal
cortex (PFC) and are targets of atypical antipsychotic drugs. They mediate, respectively …

Disorders of serotonergic neurotransmission are involved in disturbances of numerous
hypothalamic functions including circadian rhythm, mood, neuroendocrine functions, sleep …

The 5-HT2A receptor (5-HT2AR) and 5-HT2CR are localized to the same neurons within the
medial prefrontal cortex (mPFC), which regulates executive function, decision-making, and …

The similar pharmacology of the 5-HT1B and 5-HT1D receptors, and the lack of selective
compounds sufficiently distinguishing between the two receptor subtypes, have hampered …

Serotoninergic terminals are found throughout the brain, suggesting an involvement of 5-HT
in many brain functions. The effects of 5-HT on a given neuron are dependent on the …

Brain serotonergic circuitries interact with other neurotransmitter systems on a multitude of
different molecular levels. In humans, as in other mammalian species, serotonin (5-HT) …

Neural function within the medial prefrontal cortex (mPFC) regulates normal cognition,
attention and impulse control, implicating neuroregulatory abnormalities within this region in …

Although serotonin (5-hydroxytryptamine, 5-HT) is known to exert a modulatory action on
cerebellar function, our current knowledge of the nature of receptor subtypes mediating …