In this comprehensive meta-regression analysis encompassing 79 randomized controlled
trials, we observed that in populations assigned to a high sodium intake level exceeding 94 …

Sodium is an essential nutrient. Increasing sodium intake is associated with increasing
blood pressure, whereas low sodium intake results in increased renin and aldosterone …

Background Idiopathic hyperaldosteronism (IHA) is one of the most common types of
primary aldosteronism (PA), an important cause of hypertension. Although high dietary …

BACKGROUND In cross-sectional studies, the aldosterone-to-renin ratio (ARR) has been
reported to be associated with hypertension under conditions of higher sodium intake. The …

Increased urinary albumin excretion (UAE) is an early indicator of glomerular damage and of
increased cardiovascular risk. Systemic endothelial dysfunction, for which albuminuria is …

Background Salt sensitivity, a trait characterized by a pressor blood pressure response to
increased dietary salt intake, has been associated with higher rates of cardiovascular target …

Universal reduction in sodium intake has long been recommended, largely because of its
proven ability to lower blood pressure for some. However, multiple randomized trials have …

Avery large number of experimental and human studies independently link high dietary salt
intake and aldosterone excess to the development and progression of end-organ damage …

Primary aldosteronism is an endocrine disorder caused by excessive production of
aldosterone by the adrenal glands, and is recognized as the most important cause of …

First described in 1955 by Jerome W. Conn, primary aldosteronism (PA) today is well
established as a relevant cause of secondary hypertension and accounts for about 5–10 …