Integrating biomaterials and immunology to improve vaccines against infectious diseases

L Yenkoidiok-Douti, CM Jewell - ACS Biomaterials Science & …, 2020 - ACS Publications
Despite the success of vaccines in preventing many infectious diseases, effective vaccines
against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis …

Leveraging the modularity of biomaterial carriers to tune immune responses

SJ Tsai, SK Black, CM Jewell - Advanced functional materials, 2020 - Wiley Online Library
Biomaterial carriers offer modular features to control the delivery and presentation of
vaccines and immunotherapies. This tunability is a distinct capability of biomaterials …

Improving vaccine and immunotherapy design using biomaterials

ML Bookstaver, SJ Tsai, JS Bromberg, CM Jewell - Trends in immunology, 2018 - cell.com
Polymers, lipids, scaffolds, microneedles, and other biomaterials are rapidly emerging as
technologies to improve the efficacy of vaccines against infectious disease and …

Materials‐based vaccines for infectious diseases

Y Bo, H Wang - Wiley Interdisciplinary Reviews: Nanomedicine …, 2022 - Wiley Online Library
Infectious diseases that result from pathogen infection are among the leading causes of
human death, with pathogens such as human immunodeficiency virus, malaria, influenza …

Biomaterials-Based Vaccination Strategies for the Induction of CD8+T Cell Responses

CB Chesson, S Ekpo-Otu, JJ Endsley… - … Biomaterials Science & …, 2017 - ACS Publications
Natural and synthetic biomaterials are increasingly being used for the development of
vaccines and immunotherapies as alternatives to traditional live-attenuated formulations due …

Biomaterials, biological molecules, and polymers in developing vaccines

SP Ravi, Y Shamiya, A Chakraborty, C Elias… - Trends in …, 2021 - cell.com
Vaccines have been used to train the immune system to recognize pathogens, and prevent
and treat diseases, such as cancer, for decades. However, there are continuing challenges …

Engineering biomaterials to direct innate immunity

RS Oakes, E Froimchuk, CM Jewell - Advanced therapeutics, 2019 - Wiley Online Library
Small alterations during early stages of innate immune response can drive large changes in
how adaptive immune cells develop and function during protective immunity or disease …

Material matters: exploring the interplay between natural biomaterials and host immune system

AS Tripathi, MEA Zaki, SA Al-Hussain… - Frontiers in …, 2023 - frontiersin.org
Biomaterials are widely used for various medical purposes, for instance, implants, tissue
engineering, medical devices, and drug delivery systems. Natural biomaterials can be …

Engineering vaccines and niches for immune modulation

A Purwada, K Roy, A Singh - Acta biomaterialia, 2014 - Elsevier
Controlled modulation of immune response, especially the balance between
immunostimulatory and immunosuppressive responses, is critical for a variety of clinical …

Biomaterials-mediated engineering of the immune system

C Backlund, S Jalili-Firoozinezhad… - Annual review of …, 2023 - annualreviews.org
Modulation of the immune system is an important therapeutic strategy in a wide range of
diseases, and is fundamental to the development of vaccines. However, optimally safe and …