In Silico Screening and Evolution of Promising Novel Anti-Virulents Against Salmonella ATPase

L Xu, N Shen - 2023 - chemrxiv.org
Our current treatments for bacterial infections are under threat by the growth of antibiotic
resistance in many different pathogens. Of these pathogens, Salmonella is a particularly …

[PDF][PDF] Targeting the Invasion Protein A from the Type Three Secretion System of Salmonella Typhi: A Comprehensive Computational Drug Design Approach

NL SWATHI - 2023 - researchgate.net
Abstract Background: Salmonella enterica serovar Typhi is a significant human pathogen
causing enteric typhoid fever. Multidrug-resistant strains have emerged due to indiscriminate …

[HTML][HTML] High-Throughput Chemical Screening for Inhibitors of Salmonella Pathogenicity Island 2

CN Tsai, BK Coombes - STAR protocols, 2020 - Elsevier
Anti-virulence therapies are under active investigation as antibiotic alternatives; however,
their identification from large-scale chemical libraries poses a unique challenge. The …

Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity

A Boudrioua, JD Joiner, I Grin, T Kronenberger… - bioRxiv, 2024 - biorxiv.org
The enteric pathogen Salmonella enterica serovar Typhimurium relies on the activity of
effector proteins to invade, replicate, and disseminate into host epithelial cells and other …

Deployment of in-silico analysis to reveal the antibacterial profiles of Allium sativum against Aeromonas hydrophila

MK Savita, V Dwivedi, P Srivastava - Journal of Biomolecular …, 2023 - Taylor & Francis
The key challenges in aquaculture are the emergence of antimicrobial resistance in fish
cultivation due to the frequent use of antibiotics. Over the past three decades, this led to a …

Computational evaluation of efflux pump homologues and lignans as potent inhibitors against multidrug-resistant Salmonella typhi

I Shafique, M Rafiq, NF Rana, F Menaa, F Almalki… - PloS one, 2024 - journals.plos.org
Typhoid fever, caused by Salmonella enterica serovar typhi, presents a substantial global
health threat, particularly in regions with limited healthcare infrastructure. The rise of …

[PDF][PDF] Identification of a novel therapeutic target against XDR Salmonella Typhi H58 using genomics driven approach followed up by natural products virtual …

K Jalal, K Khan, M Hassam, MN Abbas, R Uddin… - 2021 - academia.edu
Typhoid fever is caused by a pathogenic, rod-shaped, flagellated, and Gram-negative
bacterium known as Salmonella Typhi. It features a polysaccharide capsule that acts as a …

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

S Mujawar, D Gatherer, C Lahiri - Frontiers in cellular and infection …, 2018 - frontiersin.org
Over recent years, typhoid fever has gained increasing attention with several cases
reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica …

Dual transcriptome based reconstruction of Salmonella-human integrated metabolic network to screen potential drug targets

K Kocabaş, A Arif, R Uddin, T Çakır - Plos one, 2022 - journals.plos.org
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a highly adaptive pathogenic
bacteria with a serious public health concern due to its increasing resistance to antibiotics …

Identification of Potential Therapeutics to Conquer Drug Resistance in Salmonella typhimurium: Drug Repurposing Strategy

B Preethi, V Shanthi, K Ramanathan - BioDrugs, 2016 - Springer
Background Salmonella typhimurium is the main cause of gastrointestinal illness in humans,
and treatment options are decreasing because drug-resistant strains have emerged …