The acetylation status of histones located in both oncogenes and tumor suppressor genes
modulate cancer hallmarks. In lung cancer, changes in the acetylation status are associated …

Epigenetic modulation, including acetylation, methylation, phosphorylation, and
ubiquitination, plays a pivotal role in regulation of gene expression. Histone acetylation—a …

Non-small cell lung cancer constitutes the most common type of lung cancer, accounting for
85-90% of lung cancer, and is a leading cause of cancer-related death. Despite the progress …

Purpose Deoxyribonucleic acid is wrapped around an octamer of core histone proteins to
form a nucleosome, the basic structure of chromatin. Two main families of enzymes maintain …

The back-breaking resistance mechanisms generated by lung cancer cells against
epidermal growth factor receptor (EGFR), KRAS and Janus kinase 2 (JAK2) directed …

Genetic abnormalities have been conventionally considered as hallmarks of cancer.
However, studies over the past decades have demonstrated that epigenetic regulation also …

Histone deacetylase inhibitors are novel anticancer agents in clinical development that
target the family of histone deacetylase (HDAC) enzymes responsible for deacetylating core …

The balance of histone acetylation and deacetylation is an epigenetic layer with a critical
role in the regulation of gene expression. Histone acetylation induced by histone acetyl …

Cancer is a pathologic condition that involves genetic and epigenetic events culminating in
neoplastic transformation. Alteration in epigenetic events that regulate the transcriptional …

Over decades of studies, accumulating evidence has suggested that epigenetic
dysregulation is a hallmark of tumours. Post-translational modifications of histones are …