[HTML][HTML] Maraviroc inhibits SARS-CoV-2 multiplication and s-protein mediated cell fusion in cell culture

KH Risner, KV Tieu, Y Wang, M Getz, A Bakovic… - BioRxiv, 2020 - ncbi.nlm.nih.gov
In an effort to identify therapeutic intervention strategies for the treatment of COVID-19, we
have investigated a selection of FDA-approved small molecules and biologics that are …

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

X Xiao, C Wang, D Chang, Y Wang, X Dong… - Frontiers in …, 2020 - frontiersin.org
COVID-19 pandemic has infected millions of people with mortality exceeding> 1 million.
There is an urgent need to find therapeutic agents that can help clear the virus to prevent …

Discovery of re-purposed drugs that slow SARS-CoV-2 replication in human cells

A Pickard, BC Calverley, J Chang, R Garva… - PLoS …, 2021 - journals.plos.org
COVID-19 vaccines based on the Spike protein of SARS-CoV-2 have been developed that
appear to be largely successful in stopping infection. However, therapeutics that can help …

On-target versus off-target effects of drugs inhibiting the replication of SARS-CoV-2

A Sauvat, F Ciccosanti, F Colavita, M Di Rienzo… - Cell Death & …, 2020 - nature.com
The current epidemic of coronavirus disease-19 (COVID-19) caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2) calls for the development of inhibitors of …

A simplified quantitative real-time PCR assay for monitoring SARS-CoV-2 growth in cell culture

C Shema Mugisha, HR Vuong, M Puray-Chavez… - MSphere, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions within
just a few months, causing severe respiratory disease and mortality. Assays to monitor …

Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro

K Shionoya, M Yamasaki, S Iwanami, Y Ito… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) has caused serious public health, social, and
economic damage worldwide and effective drugs that prevent or cure COVID-19 are …

Drug synergy of combinatory treatment with remdesivir and the repurposed drugs fluoxetine and itraconazole effectively impairs SARS‐CoV‐2 infection in vitro

S Schloer, L Brunotte… - British journal of …, 2021 - Wiley Online Library
Background and Purpose The SARS‐COV‐2 pandemic and the global spread of
coronavirus disease 2019 (COVID‐19) urgently call for efficient and safe antiviral treatment …

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

H Ohashi, K Watashi, W Saso, K Shionoya, S Iwanami… - BioRxiv, 2020 - biorxiv.org
Antiviral treatments targeting the emerging coronavirus disease 2019 (COVID-19) are
urgently required. We screened a panel of already-approved drugs in a cell culture model of …

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in …

IL Shytaj, M Fares, L Gallucci, B Lucic, MM Tolba… - Mbio, 2022 - Am Soc Microbiol
Combinations of direct-acting antivirals are needed to minimize drug resistance mutations
and stably suppress replication of RNA viruses. Currently, there are limited therapeutic …

A quantitative model used to compare within-host SARS-CoV-2, MERS-CoV, and SARS-CoV dynamics provides insights into the pathogenesis and treatment of SARS …

KS Kim, K Ejima, S Iwanami, Y Fujita, H Ohashi… - PLoS …, 2021 - journals.plos.org
The scientific community is focused on developing antiviral therapies to mitigate the impacts
of the ongoing novel coronavirus disease 2019 (COVID-19) outbreak. This will be facilitated …