Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32
recurrently mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH …

Pancreatic cancer expression profiles largely reflect a classical or basal-like phenotype. The
extent to which these profiles vary within a patient is unknown. We integrated evolutionary …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development. The current model of …

Pancreatic cancer remains one of the most lethal of malignancies and a major health
burden. We performed whole-genome sequencing and copy number variation (CNV) …

Pancreatic cancer is a highly lethal malignancy with few effective therapies. We performed
exome sequencing and copy number analysis to define genomic aberrations in a …

The poor correlation of mutational landscapes with phenotypes limits our understanding of
the pathogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC). Here we …

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease. Overall survival is typically 6
months from diagnosis 1. Numerous phase 3 trials of agents effective in other malignancies …

Most adult carcinomas develop from noninvasive precursor lesions, a progression that is
supported by genetic analysis. However, the evolutionary and genetic relationships among …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in
patients. The basis of this disease heterogeneity has proved difficult to resolve due to poor …

There are currently few therapeutic options for patients with pancreatic cancer, and new
insights into the pathogenesis of this lethal disease are urgently needed. Toward this end …