Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Silicosis is a potentially fatal, irreversible, fibrotic pulmonary disease that may develop
subsequent to the inhalation of large amounts of silica dust over time. In most circumstances …

Silicosis is the most common pneumoconiosis globally, with higher prevalence and
incidence in developing countries. To date, there is no effective treatment to halt or reverse …

Silicosis is caused by massive inhalation of silica-based particles, which leads to pulmonary
inflammation, pulmonary fibrosis and lung dysfunction. Currently, the pathophysiological …

Silicosis remains one of the most severe pulmonary fibrotic diseases worldwide, caused by
chronic exposure to silica dust. In this review, we have proposed that programmed cell death …

Silicosis is caused by the inhalation of crystalline silica (silicon dioxide, SiO2) in various
forms. This review proposes that the cascade of inflammatory and fibrotic events involved in …

While silica particles are considered to be fibrogenic and carcinogenic agents, the
mechanisms responsible are not well understood. This article summarizes literature on silica …

Silicosis is a fatal fibrotic lung disease caused by long-term silica particle exposure, in which
pulmonary macrophages play an important role. However, the relationship between …

Further research on the molecular mechanisms involved in the inflammatory processes
important for progression to fibrotic diseases is needed for the development of effective …

Silicosis is pneumoconiosis of the lung, usually resulting from prolonged exposure to
crystalline silica (CS). The hallmark of silicosis is excessive extracellular matrix (ECM) …