Regucalcin downregulation in human cancer
NZ Ghanem, M Yamaguchi - Life Sciences, 2024 - Elsevier
Regucalcin is a unique calcium-binding protein first discovered in rat liver in 1978.
Regucalcin has multiple functions as an inhibitor of various cellular signaling pathways that …
Regucalcin has multiple functions as an inhibitor of various cellular signaling pathways that …
Regucalcin Is a Potential Regulator in Human Cancer: Aiming to Expand into Cancer Therapy
M Yamaguchi - Cancers, 2023 - mdpi.com
Simple Summary Regucalcin plays a multifunctional role in the regulation of cell function
and expresses a repressive effect in the growth of normal cells. Of note, there is increasing …
and expresses a repressive effect in the growth of normal cells. Of note, there is increasing …
Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy
M Yamaguchi - Journal of cancer research and clinical oncology, 2015 - Springer
Regucalcin, which its gene is located on the X chromosome, plays a multifunctional role as a
suppressor protein in cell signal transduction in various types of cells and tissues. The …
suppressor protein in cell signal transduction in various types of cells and tissues. The …
[HTML][HTML] Prolonged survival of patients with colorectal cancer is associated with a higher regucalcin gene expression: Overexpression of regucalcin suppresses the …
M Yamaguchi, S Osuka… - … journal of oncology, 2018 - spandidos-publications.com
Regucalcin plays a crucial role as a regulator of transcriptional signaling activity, and its
decreased expression or activity may contribute to the promotion of human carcinogenesis …
decreased expression or activity may contribute to the promotion of human carcinogenesis …
Regucalcin is under‐expressed in human breast and prostate cancers: Effect of sex steroid hormones
Regucalcin plays an important role in maintenance of intracellular Ca2+ homeostasis,
suppresses cell proliferation, inhibits expression of oncogenes, and increases the …
suppresses cell proliferation, inhibits expression of oncogenes, and increases the …
Exogenous regucalcin suppresses the growth of human liver cancer HepG2 cells in vitro
M Yamaguchi, T Murata - Oncology reports, 2018 - spandidos-publications.com
Regucalcin, which its gene is localized on the X chromosome, plays a pivotal role as a
suppressor protein in signal transduction in various types of cells and tissues. Regucalcin …
suppressor protein in signal transduction in various types of cells and tissues. Regucalcin …
Alternatively spliced variants of the regucalcin gene in various human normal and tumor tissues
T Murata, M Yamaguchi - International journal of …, 2014 - spandidos-publications.com
Regucalcin plays a pivotal role as a suppressor protein in signal transduction in various cell
types. The regucalcin gene, which is localized on the X chromosome, consists of 7 exons …
types. The regucalcin gene, which is localized on the X chromosome, consists of 7 exons …
Survival of lung cancer patients is prolonged with higher regucalcin gene expression: suppressed proliferation of lung adenocarcinoma A549 cells in vitro
M Yamaguchi, S Osuka, M Shoji… - Molecular and cellular …, 2017 - Springer
Regucalcin plays a crucial role as a suppressor of transcription signaling, and its diminished
expression or activity may play a key role in human carcinogenesis. Higher regucalcin …
expression or activity may play a key role in human carcinogenesis. Higher regucalcin …
Role of regucalcin in maintaining cell homeostasis and function
M Yamaguchi - International journal of molecular …, 2005 - spandidos-publications.com
Regucalcin was discovered in 1978 as a Ca2+-binding protein that does not contain EF-
hand motif of Ca2+-binding domain. The name regucalcin was proposed for this Ca22+ …
hand motif of Ca2+-binding domain. The name regucalcin was proposed for this Ca22+ …
Prolonged survival in pancreatic cancer patients with increased regucalcin gene expression: Overexpression of regucalcin suppresses the proliferation in human …
M Yamaguchi, S Osuka… - International …, 2016 - spandidos-publications.com
Approximately 90% of all pancreatic cancers are pancreatic ductal adenocarcinomas
(PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor …
(PDAC). PDAC is a highly aggressive malignancy and is one of the deadliest. This poor …