Increased levels of homocysteine have been established as a risk factor for cardiovascular
disease (CVD) by mechanisms still incompletely defined. S-Adenosylhomocysteine (SAH) is …

Atherosclerosis is associated with multiple genetic and modifiable risk factors. There is an
increasing body of evidences to indicate that epigenetic mechanisms also play an essential …

Hyperhomocysteinaemia has been regarded as a new modifiable risk factor for
atherosclerosis and vascular disease. Homocysteine is a branch‐point intermediate of …

Transmethylation reactions utilize S-adenosylmethionine (SAM) as a methyl donor and are
central to the regulation of many biological processes: more than fifty SAM-dependent …

Hyperhomocysteinemia is an independent risk factor for cardiovascular disease.
Homocysteine (Hcy) metabolism involves multiple enzymes; however, tissue Hcy …

Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for
cardiovascular disease. This fact has produced a new, increased interest in the study of …

Cardiovascular disease is the leading cause of mortality and disability in the western world.
In the last years, the accumulation of evidence coming from both retrospective and …

High levels of homocysteine, a sulfur-containing amino acid derived from methionine, have
recently been identified as a very important risk factor in cardiovascular disease …

Chronic nutritional deficiencies in folate, choline, methionine, vitamin B-6 and/or vitamin B-
12 can perturb the complex regulatory network that maintains normal one-carbon …

Increased homocysteine levels can be responsible for arterial ischemic events, such as MI,
stroke or peripheral vascular disease. Homocysteine is metabolized by two pathways: re …