Diabetic retinal neurodegeneration as a form of diabetic retinopathy

D Soni, P Sagar, B Takkar - International Ophthalmology, 2021 - Springer
Purpose To review the evidence supporting diabetic retinal neurodegeneration (DRN) as a
form of diabetic retinopathy. Method Review of literature. Results DRN is recognized to be a …

[HTML][HTML] Retinal neurodegeneration in diabetes: an emerging concept in diabetic retinopathy

MM Sachdeva - Current diabetes reports, 2021 - Springer
Abstract Purpose of Review Diabetic retinopathy (DR), the leading cause of blindness in
working-aged adults, remains clinically defined and staged by its vascular manifestations …

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

EH Sohn, HW van Dijk, C Jiao… - Proceedings of the …, 2016 - National Acad Sciences
Diabetic retinopathy (DR) has long been recognized as a microvasculopathy, but retinal
diabetic neuropathy (RDN), characterized by inner retinal neurodegeneration, also occurs in …

Diabetic retinopathy: neuron protection as a therapeutic target

X Zhang, N Wang, GR Barile, S Bao, M Gillies - The international journal of …, 2013 - Elsevier
Diabetic retinopathy (DR) has mainly been regarded as a microvascular disease that is
caused by hyperglycaemia and characterized by retinal vascular leakage, macular oedema …

[HTML][HTML] Diabetic retinopathy is a neurodegenerative disorder

SK Lynch, MD Abràmoff - Vision research, 2017 - Elsevier
Since 1875, controversy has ensued over whether ocular diabetic complications are
primarily vasculopathic or neuropathic in nature. Here, we discuss the historical context by …

Neurodegeneration and neuroinflammation in diabetic retinopathy: potential approaches to delay neuronal loss

L Malaguarnera, K Zorena - Current neuropharmacology, 2016 - ingentaconnect.com
In spite of the extensive research the complex pathogenesis of diabetic retinopathy (DR) has
not been fully elucidated. For many years it has been thought that diabetic retinopathy …

[HTML][HTML] Neurodegeneration in diabetic retinopathy: does it really matter?

R Simó, AW Stitt, TW Gardner - Diabetologia, 2018 - Springer
The concept of diabetic retinopathy as a microvascular disease has evolved, in that it is now
considered a more complex diabetic complication in which neurodegeneration plays a …

[HTML][HTML] Neuroretinal alterations in the early stages of diabetic retinopathy in patients with type 2 diabetes mellitus

P Carpineto, L Toto, R Aloia, V Ciciarelli, E Borrelli… - Eye, 2016 - nature.com
Neuroretinal alterations in the early stages of diabetic retinopathy in patients with type 2
diabetes mellitus | Eye Skip to main content Thank you for visiting nature.com. You are using …

[HTML][HTML] Retinal cell damage in diabetic retinopathy

J Zhou, B Chen - Cells, 2023 - mdpi.com
Diabetic retinopathy (DR), the most common microvascular complication that occurs in
diabetes mellitus (DM), is the leading cause of vision loss in working-age adults. The …

[HTML][HTML] Neurodegeneration in diabetic retinopathy: potential for novel therapies

AJ Barber, B Baccouche - Vision research, 2017 - Elsevier
The complex pathology of diabetic retinopathy (DR) affects both vascular and neural tissue.
The characteristics of neurodegeneration are well-described in animal models but have …