Regulatory T cells (Tregs) characterized by the expression of the master transcription factor
forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective …

CD4+ Foxp3+ regulatory T cells (Tregs) have a fundamental role in maintaining immune
balance by preventing autoreactivity and immune-mediated pathology. However this role of …

The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …

Due to the critical role of forkhead box (Fox) p3+ regulatory T cells (Tregs) in the regulation
of immunity and the enrichment of Tregs within many human tumors, several emerging …

The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …

Regulatory T cells (Tregs) expressing forkhead/winged-helix transcription factor Foxp3
represent a distinct lineage of lymphocytes which play a central role in protecting the host …

Cancer immunotherapy involving blockade of immune checkpoint molecules, such as CTLA‐
4 and PD‐1, has shown remarkable clinical success across several types of malignancies …

In immunocompetent individuals, the immune system initially eradicates potentially
tumorigenic cells as they develop, a capacity that is progressively lost when malignant cells …

Introduction: Regulatory T cells (Tregs) accumulating in the peripheral circulation and tumor
sites of patients contribute to tumor escape from the host immune system. Tregs encompass …

The immune system has evolved complex effector mechanisms to protect the host against a
diversity of pathogenic organisms and regulatory adaptations that can curtail pathological …