Monocyte maturation, HIV susceptibility, and transmigration across the blood brain barrier are critical in HIV neuropathogenesis

DW Williams, EA Eugenin, TM Calderon… - Journal of leukocyte …, 2012 - academic.oup.com
ABSTRACT HIV continues to be a global health crisis with more than 34 million people
infected worldwide (UNAIDS: Report on the Global AIDS Epidemic 2010, Geneva, World …

Characterization of monocyte maturation/differentiation that facilitates their transmigration across the blood–brain barrier and infection by HIV: implications for …

CM Buckner, TM Calderon, DW Willams, TJ Belbin… - Cellular …, 2011 - Elsevier
The prevalence of human immunodeficiency virus 1 (HIV) associated neurocognitive
disorders resulting from infection of the central nervous system (CNS) by HIV continues to …

Monocytes mediate HIV neuropathogenesis: mechanisms that contribute to HIV associated neurocognitive disorders

DW Williams, M Veenstra, PJ Gaskill… - Current HIV …, 2014 - ingentaconnect.com
HIV infected people are living longer due to the success of combined antiretroviral therapy
(cART). However, greater than 40-70% of HIV infected individuals develop HIV associated …

Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated …

M Veenstra, R León-Rivera, M Li, L Gama… - MBio, 2017 - Am Soc Microbiol
ABSTRACT HIV reservoirs persist despite antiretroviral therapy (ART) and are established
within a few days after infection. Infected myeloid cells in the central nervous system (CNS) …

Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection

G Gras, M Kaul - Retrovirology, 2010 - Springer
HIV associated neurocognitive disorders and their histopathological correlates largely
depend on the continuous seeding of the central nervous system with immune activated …

Neuroimmunity and the blood–brain barrier: molecular regulation of leukocyte transmigration and viral entry into the nervous system with a focus on neuroAIDS

CM Buckner, AJ Luers, TM Calderon… - Journal of Neuroimmune …, 2006 - Springer
HIV infection of the central nervous system (CNS) can result in neurologic dysfunction with
devastating consequences in a significant number of individuals with AIDS. Two main CNS …

CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood–brain …

EA Eugenin, K Osiecki, L Lopez… - Journal of …, 2006 - Soc Neuroscience
Encephalitis and dementia associated with acquired immunodeficiency syndrome (AIDS)
are characterized by leukocyte infiltration into the CNS, microglia activation, aberrant …

Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in …

DW Williams, TM Calderon, L Lopez, L Carvallo-Torres… - PloS one, 2013 - journals.plos.org
As HIV infected individuals live longer, the prevalence of HIV associated neurocognitive
disorders is increasing, despite successful antiretroviral therapy. CD14+ CD16+ monocytes …

Neuroinvasion of fluorescein-positive monocytes in acute simian immunodeficiency virus infection

CC Clay, DS Rodrigues, YS Ho, BA Fallert… - Journal of …, 2007 - Am Soc Microbiol
Monocytes and macrophages play a central role in the pathogenesis of human
immunodeficiency virus (HIV)-associated dementia. They represent prominent targets for …

Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis

Y Persidsky, A Ghorpade, J Rasmussen… - The American journal of …, 1999 - Elsevier
The numbers of immune-activated brain mononuclear phagocytes (MPs. affect the
progression of human immunodeficiency virus (HIV)-1-associated dementia (HAD). Such …